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Innate Immune Responses to Cryptococcus
Cryptococcus species are encapsulated fungi found in the environment that predominantly cause disease in immunocompromised hosts after inhalation into the lungs. Even with contemporary antifungal regimens, patients with cryptococcosis continue to have high morbidity and mortality rates. The developm...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604851/ https://www.ncbi.nlm.nih.gov/pubmed/28936464 http://dx.doi.org/10.3390/jof3030035 |
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author | Heung, Lena J. |
author_facet | Heung, Lena J. |
author_sort | Heung, Lena J. |
collection | PubMed |
description | Cryptococcus species are encapsulated fungi found in the environment that predominantly cause disease in immunocompromised hosts after inhalation into the lungs. Even with contemporary antifungal regimens, patients with cryptococcosis continue to have high morbidity and mortality rates. The development of more effective therapies may depend on our understanding of the cellular and molecular mechanisms by which the host promotes sterilizing immunity against the fungus. This review will highlight our current knowledge of how Cryptococcus, primarily the species C. neoformans, is sensed by the mammalian host and how subsequent signaling pathways direct the anti-cryptococcal response by effector cells of the innate immune system. |
format | Online Article Text |
id | pubmed-5604851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-56048512017-09-19 Innate Immune Responses to Cryptococcus Heung, Lena J. J Fungi (Basel) Review Cryptococcus species are encapsulated fungi found in the environment that predominantly cause disease in immunocompromised hosts after inhalation into the lungs. Even with contemporary antifungal regimens, patients with cryptococcosis continue to have high morbidity and mortality rates. The development of more effective therapies may depend on our understanding of the cellular and molecular mechanisms by which the host promotes sterilizing immunity against the fungus. This review will highlight our current knowledge of how Cryptococcus, primarily the species C. neoformans, is sensed by the mammalian host and how subsequent signaling pathways direct the anti-cryptococcal response by effector cells of the innate immune system. MDPI 2017-07-02 /pmc/articles/PMC5604851/ /pubmed/28936464 http://dx.doi.org/10.3390/jof3030035 Text en © 2017 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Heung, Lena J. Innate Immune Responses to Cryptococcus |
title | Innate Immune Responses to Cryptococcus |
title_full | Innate Immune Responses to Cryptococcus |
title_fullStr | Innate Immune Responses to Cryptococcus |
title_full_unstemmed | Innate Immune Responses to Cryptococcus |
title_short | Innate Immune Responses to Cryptococcus |
title_sort | innate immune responses to cryptococcus |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604851/ https://www.ncbi.nlm.nih.gov/pubmed/28936464 http://dx.doi.org/10.3390/jof3030035 |
work_keys_str_mv | AT heunglenaj innateimmuneresponsestocryptococcus |