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Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation

Protein kinase C (PKC) has been shown to activate the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, a central hub in the regulation of cell metabolism, growth and proliferation. However, the mechanisms by which PKCs activate mTORC1 are still ambiguous. Our previous study reveal...

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Detalles Bibliográficos
Autores principales:	Liu, Mengling, Clarke, Christopher J., Salama, Mohamed F., Choi, Yeon Ja, Obeid, Lina M., Hannun, Yusuf A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604983/ https://www.ncbi.nlm.nih.gov/pubmed/28926616 http://dx.doi.org/10.1371/journal.pone.0184818

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