Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus

Activation of the unfolded protein response (UPR) in eukaryotic cells represents an evolutionarily conserved response to physiological stress. Here, we report that the mTOR inhibitors rapamycin (sirolimus) and structurally related temsirolimus are capable of inducing UPR in sarcoma cells. However, t...

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Detalles Bibliográficos
Autores principales: Briggs, Joseph W., Ren, Ling, Chakrabarti, Kristi R., Tsai, Yien Che, Weissman, Allan M., Hansen, Ryan J., Gustafson, Daniel L., Khan, Yousuf A., Dinman, Jonathan D., Khanna, Chand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605117/
https://www.ncbi.nlm.nih.gov/pubmed/28926611
http://dx.doi.org/10.1371/journal.pone.0185089

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