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Avoidance of APOBEC3B-induced mutation by error-free lesion bypass

APOBEC cytidine deaminases mutate cancer genomes by converting cytidines into uridines within ssDNA during replication. Although uracil DNA glycosylases limit APOBEC-induced mutation, it is unknown if subsequent base excision repair (BER) steps function on replication-associated ssDNA. Hence, we mea...

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Detalles Bibliográficos
Autores principales:	Hoopes, James I., Hughes, Amber L., Hobson, Lauren A., Cortez, Luis M., Brown, Alexander J., Roberts, Steven A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605239/ https://www.ncbi.nlm.nih.gov/pubmed/28334887 http://dx.doi.org/10.1093/nar/gkx169

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