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Intra-endosomal trafficking mediated by lysobisphosphatidic acid contributes to intracellular release of phosphorothioate-modified antisense oligonucleotides

Antisense oligonucleotides (ASOs) with phosphorothioate (PS) linkages are broadly used as research tools and therapeutic agents. Chemically modified PS-ASOs can mediate efficient target reduction by site-specific cleavage of RNA through RNase H1. PS-ASOs are known to be internalized via a number of...

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Detalles Bibliográficos
Autores principales:	Wang, Shiyu, Sun, Hong, Tanowitz, Michael, Liang, Xue-hai, Crooke, Stanley T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605259/ https://www.ncbi.nlm.nih.gov/pubmed/28379543 http://dx.doi.org/10.1093/nar/gkx231

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