Cargando…
Advancing functional dysconnectivity and atrophy in progressive supranuclear palsy
Progressive supranuclear palsy syndrome (PSP-S) results from neurodegeneration within a network of brainstem, subcortical, frontal and parietal cortical brain regions. It is unclear how network dysfunction progresses and relates to longitudinal atrophy and clinical decline. In this study, we evaluat...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605489/ https://www.ncbi.nlm.nih.gov/pubmed/28951832 http://dx.doi.org/10.1016/j.nicl.2017.09.008 |
_version_ | 1783264987631845376 |
---|---|
author | Brown, Jesse A. Hua, Alice Y. Trujillo, Andrew Attygalle, Suneth Binney, Richard J. Spina, Salvatore Lee, Suzee E. Kramer, Joel H. Miller, Bruce L. Rosen, Howard J. Boxer, Adam L. Seeley, William W. |
author_facet | Brown, Jesse A. Hua, Alice Y. Trujillo, Andrew Attygalle, Suneth Binney, Richard J. Spina, Salvatore Lee, Suzee E. Kramer, Joel H. Miller, Bruce L. Rosen, Howard J. Boxer, Adam L. Seeley, William W. |
author_sort | Brown, Jesse A. |
collection | PubMed |
description | Progressive supranuclear palsy syndrome (PSP-S) results from neurodegeneration within a network of brainstem, subcortical, frontal and parietal cortical brain regions. It is unclear how network dysfunction progresses and relates to longitudinal atrophy and clinical decline. In this study, we evaluated patients with PSP-S (n = 12) and healthy control subjects (n = 20) at baseline and 6 months later. Subjects underwent structural MRI and task-free functional MRI (tf-fMRI) scans and clinical evaluations at both time points. At baseline, voxel based morphometry (VBM) revealed that patients with mild-to-moderate clinical symptoms showed structural atrophy in subcortex and brainstem, prefrontal cortex (PFC; supplementary motor area, paracingulate, dorsal and ventral medial PFC), and parietal cortex (precuneus). Tf-fMRI functional connectivity (FC) was examined in a rostral midbrain tegmentum (rMT)-anchored intrinsic connectivity network that is compromised in PSP-S. In healthy controls, this network contained a medial parietal module, a prefrontal-paralimbic module, and a subcortical-brainstem module. Baseline FC deficits in PSP-S were most severe in rMT network integrative hubs in the prefrontal-paralimbic and subcortical-brainstem modules. Longitudinally, patients with PSP-S had declining intermodular FC between the subcortical-brainstem and parietal modules, while progressive atrophy was observed in subcortical-brainstem regions (midbrain, pallidum) and posterior frontal (perirolandic) cortex. This suggested that later-stage subcortical-posterior cortical change may follow an earlier-stage subcortical-anterior cortical disease process. Clinically, patients with more severe baseline impairment showed greater subsequent prefrontal-parietal cortical FC declines and posterior frontal atrophy rates, while patients with more rapid longitudinal clinical decline showed coupled prefrontal-paralimbic FC decline. VBM and FC can augment disease monitoring in PSP-S by tracking the disease through stages while detecting changes that accompany heterogeneous clinical progression. |
format | Online Article Text |
id | pubmed-5605489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-56054892017-09-26 Advancing functional dysconnectivity and atrophy in progressive supranuclear palsy Brown, Jesse A. Hua, Alice Y. Trujillo, Andrew Attygalle, Suneth Binney, Richard J. Spina, Salvatore Lee, Suzee E. Kramer, Joel H. Miller, Bruce L. Rosen, Howard J. Boxer, Adam L. Seeley, William W. Neuroimage Clin Regular Article Progressive supranuclear palsy syndrome (PSP-S) results from neurodegeneration within a network of brainstem, subcortical, frontal and parietal cortical brain regions. It is unclear how network dysfunction progresses and relates to longitudinal atrophy and clinical decline. In this study, we evaluated patients with PSP-S (n = 12) and healthy control subjects (n = 20) at baseline and 6 months later. Subjects underwent structural MRI and task-free functional MRI (tf-fMRI) scans and clinical evaluations at both time points. At baseline, voxel based morphometry (VBM) revealed that patients with mild-to-moderate clinical symptoms showed structural atrophy in subcortex and brainstem, prefrontal cortex (PFC; supplementary motor area, paracingulate, dorsal and ventral medial PFC), and parietal cortex (precuneus). Tf-fMRI functional connectivity (FC) was examined in a rostral midbrain tegmentum (rMT)-anchored intrinsic connectivity network that is compromised in PSP-S. In healthy controls, this network contained a medial parietal module, a prefrontal-paralimbic module, and a subcortical-brainstem module. Baseline FC deficits in PSP-S were most severe in rMT network integrative hubs in the prefrontal-paralimbic and subcortical-brainstem modules. Longitudinally, patients with PSP-S had declining intermodular FC between the subcortical-brainstem and parietal modules, while progressive atrophy was observed in subcortical-brainstem regions (midbrain, pallidum) and posterior frontal (perirolandic) cortex. This suggested that later-stage subcortical-posterior cortical change may follow an earlier-stage subcortical-anterior cortical disease process. Clinically, patients with more severe baseline impairment showed greater subsequent prefrontal-parietal cortical FC declines and posterior frontal atrophy rates, while patients with more rapid longitudinal clinical decline showed coupled prefrontal-paralimbic FC decline. VBM and FC can augment disease monitoring in PSP-S by tracking the disease through stages while detecting changes that accompany heterogeneous clinical progression. Elsevier 2017-09-12 /pmc/articles/PMC5605489/ /pubmed/28951832 http://dx.doi.org/10.1016/j.nicl.2017.09.008 Text en © 2017 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Brown, Jesse A. Hua, Alice Y. Trujillo, Andrew Attygalle, Suneth Binney, Richard J. Spina, Salvatore Lee, Suzee E. Kramer, Joel H. Miller, Bruce L. Rosen, Howard J. Boxer, Adam L. Seeley, William W. Advancing functional dysconnectivity and atrophy in progressive supranuclear palsy |
title | Advancing functional dysconnectivity and atrophy in progressive supranuclear palsy |
title_full | Advancing functional dysconnectivity and atrophy in progressive supranuclear palsy |
title_fullStr | Advancing functional dysconnectivity and atrophy in progressive supranuclear palsy |
title_full_unstemmed | Advancing functional dysconnectivity and atrophy in progressive supranuclear palsy |
title_short | Advancing functional dysconnectivity and atrophy in progressive supranuclear palsy |
title_sort | advancing functional dysconnectivity and atrophy in progressive supranuclear palsy |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605489/ https://www.ncbi.nlm.nih.gov/pubmed/28951832 http://dx.doi.org/10.1016/j.nicl.2017.09.008 |
work_keys_str_mv | AT brownjessea advancingfunctionaldysconnectivityandatrophyinprogressivesupranuclearpalsy AT huaalicey advancingfunctionaldysconnectivityandatrophyinprogressivesupranuclearpalsy AT trujilloandrew advancingfunctionaldysconnectivityandatrophyinprogressivesupranuclearpalsy AT attygallesuneth advancingfunctionaldysconnectivityandatrophyinprogressivesupranuclearpalsy AT binneyrichardj advancingfunctionaldysconnectivityandatrophyinprogressivesupranuclearpalsy AT spinasalvatore advancingfunctionaldysconnectivityandatrophyinprogressivesupranuclearpalsy AT leesuzeee advancingfunctionaldysconnectivityandatrophyinprogressivesupranuclearpalsy AT kramerjoelh advancingfunctionaldysconnectivityandatrophyinprogressivesupranuclearpalsy AT millerbrucel advancingfunctionaldysconnectivityandatrophyinprogressivesupranuclearpalsy AT rosenhowardj advancingfunctionaldysconnectivityandatrophyinprogressivesupranuclearpalsy AT boxeradaml advancingfunctionaldysconnectivityandatrophyinprogressivesupranuclearpalsy AT seeleywilliamw advancingfunctionaldysconnectivityandatrophyinprogressivesupranuclearpalsy |