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Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response

RIG-I and MDA5 are cytoplasmic viral RNA sensors that belong to the RIG-I-like receptors (RLRs), which induce antiviral innate immune responses, including the production of type I interferon and other pro-inflammatory cytokines. After recognition of viral RNA, the N-terminal caspase activation and r...

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Detalles Bibliográficos
Autores principales:	Kouwaki, Takahisa, Okamoto, Masaaki, Tsukamoto, Hirotake, Fukushima, Yoshimi, Matsumoto, Misako, Seya, Tsukasa, Oshiumi, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605516/ https://www.ncbi.nlm.nih.gov/pubmed/28928438 http://dx.doi.org/10.1038/s41598-017-12224-7

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