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Age-Related Changes in Perirhinal Cortex Sensitivity to Configuration and Part Familiarity and Connectivity to Visual Cortex

The perirhinal cortex (PRC) is a medial temporal lobe (MTL) structure known to be involved in assessing whether an object is familiar (i.e., meaningful) or novel. Recent evidence shows that the PRC is sensitive to the familiarity of both whole object configurations and their parts, and suggests the...

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Autores principales: Cacciamani, Laura, Wager, Erica, Peterson, Mary A., Scalf, Paige E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605556/
https://www.ncbi.nlm.nih.gov/pubmed/28966591
http://dx.doi.org/10.3389/fnagi.2017.00291
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author Cacciamani, Laura
Wager, Erica
Peterson, Mary A.
Scalf, Paige E.
author_facet Cacciamani, Laura
Wager, Erica
Peterson, Mary A.
Scalf, Paige E.
author_sort Cacciamani, Laura
collection PubMed
description The perirhinal cortex (PRC) is a medial temporal lobe (MTL) structure known to be involved in assessing whether an object is familiar (i.e., meaningful) or novel. Recent evidence shows that the PRC is sensitive to the familiarity of both whole object configurations and their parts, and suggests the PRC may modulate part familiarity responses in V2. Here, using functional magnetic resonance imaging (fMRI), we investigated age-related decline in the PRC’s sensitivity to part/configuration familiarity and assessed its functional connectivity to visual cortex in young and older adults. Participants categorized peripherally presented silhouettes as familiar (“real-world”) or novel. Part/configuration familiarity was manipulated via three silhouette configurations: Familiar (parts/configurations familiar), Control Novel (parts/configurations novel), and Part-Rearranged Novel (parts familiar, configurations novel). “Real-world” judgments were less accurate than “novel” judgments, although accuracy did not differ between age groups. The fMRI data revealed differential neural activity, however: In young adults, a linear pattern of activation was observed in left hemisphere (LH) PRC, with Familiar > Control Novel > Part-Rearranged Novel. Older adults did not show this pattern, indicating age-related decline in the PRC’s sensitivity to part/configuration familiarity. A functional connectivity analysis revealed a significant coupling between the PRC and V2 in the LH in young adults only. Older adults showed a linear pattern of activation in the temporopolar cortex (TPC), but no evidence of TPC-V2 connectivity. This is the first study to demonstrate age-related decline in the PRC’s representations of part/configuration familiarity and its covariance with visual cortex.
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spelling pubmed-56055562017-09-29 Age-Related Changes in Perirhinal Cortex Sensitivity to Configuration and Part Familiarity and Connectivity to Visual Cortex Cacciamani, Laura Wager, Erica Peterson, Mary A. Scalf, Paige E. Front Aging Neurosci Neuroscience The perirhinal cortex (PRC) is a medial temporal lobe (MTL) structure known to be involved in assessing whether an object is familiar (i.e., meaningful) or novel. Recent evidence shows that the PRC is sensitive to the familiarity of both whole object configurations and their parts, and suggests the PRC may modulate part familiarity responses in V2. Here, using functional magnetic resonance imaging (fMRI), we investigated age-related decline in the PRC’s sensitivity to part/configuration familiarity and assessed its functional connectivity to visual cortex in young and older adults. Participants categorized peripherally presented silhouettes as familiar (“real-world”) or novel. Part/configuration familiarity was manipulated via three silhouette configurations: Familiar (parts/configurations familiar), Control Novel (parts/configurations novel), and Part-Rearranged Novel (parts familiar, configurations novel). “Real-world” judgments were less accurate than “novel” judgments, although accuracy did not differ between age groups. The fMRI data revealed differential neural activity, however: In young adults, a linear pattern of activation was observed in left hemisphere (LH) PRC, with Familiar > Control Novel > Part-Rearranged Novel. Older adults did not show this pattern, indicating age-related decline in the PRC’s sensitivity to part/configuration familiarity. A functional connectivity analysis revealed a significant coupling between the PRC and V2 in the LH in young adults only. Older adults showed a linear pattern of activation in the temporopolar cortex (TPC), but no evidence of TPC-V2 connectivity. This is the first study to demonstrate age-related decline in the PRC’s representations of part/configuration familiarity and its covariance with visual cortex. Frontiers Media S.A. 2017-09-15 /pmc/articles/PMC5605556/ /pubmed/28966591 http://dx.doi.org/10.3389/fnagi.2017.00291 Text en Copyright © 2017 Cacciamani, Wager, Peterson and Scalf. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Cacciamani, Laura
Wager, Erica
Peterson, Mary A.
Scalf, Paige E.
Age-Related Changes in Perirhinal Cortex Sensitivity to Configuration and Part Familiarity and Connectivity to Visual Cortex
title Age-Related Changes in Perirhinal Cortex Sensitivity to Configuration and Part Familiarity and Connectivity to Visual Cortex
title_full Age-Related Changes in Perirhinal Cortex Sensitivity to Configuration and Part Familiarity and Connectivity to Visual Cortex
title_fullStr Age-Related Changes in Perirhinal Cortex Sensitivity to Configuration and Part Familiarity and Connectivity to Visual Cortex
title_full_unstemmed Age-Related Changes in Perirhinal Cortex Sensitivity to Configuration and Part Familiarity and Connectivity to Visual Cortex
title_short Age-Related Changes in Perirhinal Cortex Sensitivity to Configuration and Part Familiarity and Connectivity to Visual Cortex
title_sort age-related changes in perirhinal cortex sensitivity to configuration and part familiarity and connectivity to visual cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605556/
https://www.ncbi.nlm.nih.gov/pubmed/28966591
http://dx.doi.org/10.3389/fnagi.2017.00291
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