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SIRT1/Adenosine Monophosphate-Activated Protein Kinase α Signaling Enhances Macrophage Polarization to an Anti-inflammatory Phenotype in Rheumatoid Arthritis

Macrophages are crucially involved in the pathogenesis of rheumatoid arthritis (RA). Macrophages of the M1 phenotype act as pro-inflammatory mediators in synovium, whereas those of the M2 phenotype suppress inflammation and promote tissue repair. SIRT1 is a class 3 histone deacetylase with anti-infl...

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Detalles Bibliográficos
Autores principales:	Park, So Youn, Lee, Sung Won, Lee, Sang Yeob, Hong, Ki Whan, Bae, Sun Sik, Kim, Koanhoi, Kim, Chi Dae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605563/ https://www.ncbi.nlm.nih.gov/pubmed/28966618 http://dx.doi.org/10.3389/fimmu.2017.01135

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