Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis

Adenosine/adenosine receptor-mediated signaling has been implicated in the development of various ischemic diseases, including ischemic retinopathies. Here, we show that the adenosine A2a receptor (ADORA2A) promotes hypoxia-inducible transcription factor-1 (HIF-1)-dependent endothelial cell glycolys...

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Detalles Bibliográficos
Autores principales: Liu, Zhiping, Yan, Siyuan, Wang, Jiaojiao, Xu, Yiming, Wang, Yong, Zhang, Shuya, Xu, Xizhen, Yang, Qiuhua, Zeng, Xianqiu, Zhou, Yaqi, Gu, Xuejiao, Lu, Sarah, Fu, Zhongjie, Fulton, David J., Weintraub, Neal L., Caldwell, Ruth B., Zhang, Wenbo, Wu, Chaodong, Liu, Xiao-Ling, Chen, Jiang-Fan, Ahmad, Aftab, Kaddour-Djebbar, Ismail, Al-Shabrawey, Mohamed, Li, Qinkai, Jiang, Xuejun, Sun, Ye, Sodhi, Akrit, Smith, Lois, Hong, Mei, Huo, Yuqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605640/
https://www.ncbi.nlm.nih.gov/pubmed/28928465
http://dx.doi.org/10.1038/s41467-017-00551-2

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