Cargando…

Enhancing the cytotoxicity of chemoradiation with radiation-guided delivery of anti-MGMT morpholino oligonucleotides in non-methylated solid tumors

The DNA repair enzyme O(6)-methylguanine DNA methyltransferase (MGMT) is epigenetically silenced in some tumors by MGMT gene promoter methylation. MGMT-hypermethylated solid tumors have enhanced susceptibility to the cytotoxic effects of alkylating chemotherapy such as temozolomide, compared with no...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ambady, P, Wu, Y J, Walker, J M, Kersch, C, Pagel, M A, Woltjer, R L, Fu, R, Muldoon, L L, Neuwelt, E A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605678/ https://www.ncbi.nlm.nih.gov/pubmed/28752860 http://dx.doi.org/10.1038/cgt.2017.27

Ejemplares similares

Radiation enhances the delivery of antisense oligonucleotides and improves chemo-radiation efficacy in brain tumor xenografts
por: Ambady, Prakash, et al.
Publicado: (2021)

Improved Pathologic response to chemoradiation in MGMT methylated locally advanced rectal cancer
por: Jensen, Garrett L., et al.
Publicado: (2023)

Morpholino antisense oligonucleotides: tools for investigating vertebrate development
por: Corey, David R, et al.
Publicado: (2001)

AMOD: a morpholino oligonucleotide selection tool
por: Klee, Eric W., et al.
Publicado: (2005)

Nitroreductase-Activatable Morpholino Oligonucleotides for in Vivo Gene Silencing
por: Yamazoe, Sayumi, et al.
Publicado: (2014)

Defining Synphenotype Groups in Xenopus tropicalis by Use of Antisense Morpholino Oligonucleotides
por: Rana, Amer Ahmed, et al.
Publicado: (2006)

Interactions between αv-Integrin and HER2 and Their Role in the Invasive Phenotype of Breast Cancer Cells In Vitro and in Rat Brain
por: Lal, Sangeet, et al.
Publicado: (2015)

Synthesis of Backbone-Modified Morpholino Oligonucleotides Using Phosphoramidite Chemistry
por: Paul, Sibasish, et al.
Publicado: (2023)

Peptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides
por: Järver, Peter, et al.
Publicado: (2015)

Therapeutic phosphorodiamidate morpholino oligonucleotides: Physical properties, solution structures, and folding thermodynamics
por: Maksudov, Farkhad, et al.
Publicado: (2023)

Patterns of relapse in primary central nervous system lymphoma: inferences regarding the role of the neuro-vascular unit and monoclonal antibodies in treating occult CNS disease
por: Ambady, Prakash, et al.
Publicado: (2017)

Synthesis of triazole-linked morpholino oligonucleotides via Cu(I) catalysed cycloaddition
por: Palframan, Matthew J., et al.
Publicado: (2016)

Aminoglycoside Enhances the Delivery of Antisense Morpholino Oligonucleotides In Vitro and in mdx Mice
por: Wang, Mingxing, et al.
Publicado: (2019)

Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate approach
por: Tsurusaki, Taiki, et al.
Publicado: (2023)

Transcriptional signatures in histologic structures within glioblastoma tumors may predict personalized drug sensitivity and survival
por: Kersch, Cymon N, et al.
Publicado: (2020)

Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung
por: Dang, Yan, et al.
Publicado: (2021)

Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery In Vitro and in mdx Mice
por: Wang, Mingxing, et al.
Publicado: (2018)

Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle
por: Novak, James S., et al.
Publicado: (2017)

Polyquaternium-mediated delivery of morpholino oligonucleotides for exon-skipping in vitro and in mdx mice
por: Wang, Mingxing, et al.
Publicado: (2017)

Antineoplastic Effect of Decoy Oligonucleotide Derived from MGMT Enhancer
por: Canello, Tamar, et al.
Publicado: (2014)

Vascular endothelial growth factor blockade alters magnetic resonance imaging biomarkers of vascular function and decreases barrier permeability in a rat model of lung cancer brain metastasis
por: Pishko, Gregory L, et al.
Publicado: (2015)

Micromanipulation of Gene Expression in the Adult Zebrafish Brain Using Cerebroventricular Microinjection of Morpholino Oligonucleotides
por: Kizil, Caghan, et al.
Publicado: (2013)

Rapid Screening of Gene Function by Systemic Delivery of Morpholino Oligonucleotides to Live Mouse Embryos
por: McClelland, Kathryn S., et al.
Publicado: (2015)

Evaluation of Amphiphilic Peptide Modified Antisense Morpholino Oligonucleotides In Vitro and in Dystrophic mdx Mice
por: Wang, Mingxing, et al.
Publicado: (2017)

Homogeneous MGMT Immunoreactivity Correlates with an Unmethylated MGMT Promoter Status in Brain Metastases of Various Solid Tumors
por: Ingold, Barbara, et al.
Publicado: (2009)

Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide
por: van Nifterik, K A, et al.
Publicado: (2010)

Impact of delays in initiating postoperative chemoradiation while determining the MGMT promoter-methylation statuses of patients with primary glioblastoma
por: Adeberg, Sebastian, et al.
Publicado: (2015)

Cationic polyelectrolyte-mediated delivery of antisense morpholino oligonucleotides for exon-skipping in vitro and in mdx mice
por: Wang, Mingxing, et al.
Publicado: (2015)

Selective Neuromuscular Denervation in Taiwanese Severe SMA Mouse Can Be Reversed by Morpholino Antisense Oligonucleotides
por: Lin, Te-Lin, et al.
Publicado: (2016)

Antisense Morpholino Oligonucleotides Reduce Neurofilament Synthesis and Inhibit Axon Regeneration in Lamprey Reticulospinal Neurons
por: Zhang, Guixin, et al.
Publicado: (2015)

Author Correction: Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle
por: Novak, James S., et al.
Publicado: (2018)

Author Correction: Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle
por: Novak, James S., et al.
Publicado: (2018)

Shorter Phosphorodiamidate Morpholino Splice-Switching Oligonucleotides May Increase Exon-Skipping Efficacy in DMD
por: Akpulat, Ugur, et al.
Publicado: (2018)

The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse
por: Zhang, Aiping, et al.
Publicado: (2015)

Development of a general methodology for labelling peptide–morpholino oligonucleotide conjugates using alkyne–azide click chemistry
por: Shabanpoor, Fazel, et al.
Publicado: (2013)

Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy
por: Shabanpoor, Fazel, et al.
Publicado: (2017)

Scavenger Receptor Class A1 Mediates Uptake of Morpholino Antisense Oligonucleotide into Dystrophic Skeletal Muscle
por: Miyatake, Shouta, et al.
Publicado: (2019)

Safety of intra-arterial chemotherapy with or without osmotic blood–brain barrier disruption for the treatment of patients with brain tumors
por: Uluc, Kutluay, et al.
Publicado: (2022)

N-[Morpholino(phenyl)methyl]benzamide
por: Muruganandam, L., et al.
Publicado: (2009)

Association between MGMT Enhancer Methylation and MGMT Promoter Methylation, MGMT Protein Expression, and Overall Survival in Glioblastoma
por: Zappe, Katja, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_hg8brmguiet9fi4daemrmpqp7c