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The glucoregulatory actions of leptin

BACKGROUND: The hormone leptin is an important regulator of metabolic homeostasis, able to inhibit food intake and increase energy expenditure. Leptin can also independently lower blood glucose levels, particularly in hyperglycemic models of leptin or insulin deficiency. Despite significant efforts...

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Detalles Bibliográficos
Autores principales: D'souza, Anna M., Neumann, Ursula H., Glavas, Maria M., Kieffer, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605734/
https://www.ncbi.nlm.nih.gov/pubmed/28951828
http://dx.doi.org/10.1016/j.molmet.2017.04.011
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author D'souza, Anna M.
Neumann, Ursula H.
Glavas, Maria M.
Kieffer, Timothy J.
author_facet D'souza, Anna M.
Neumann, Ursula H.
Glavas, Maria M.
Kieffer, Timothy J.
author_sort D'souza, Anna M.
collection PubMed
description BACKGROUND: The hormone leptin is an important regulator of metabolic homeostasis, able to inhibit food intake and increase energy expenditure. Leptin can also independently lower blood glucose levels, particularly in hyperglycemic models of leptin or insulin deficiency. Despite significant efforts and relevance to diabetes, the mechanisms by which leptin acts to regulate blood glucose levels are not fully understood. SCOPE OF REVIEW: Here we assess literature relevant to the glucose lowering effects of leptin. Leptin receptors are widely expressed in multiple cell types, and we describe both peripheral and central effects of leptin that may be involved in lowering blood glucose. In addition, we summarize the potential clinical application of leptin in regulating glucose homeostasis. MAJOR CONCLUSIONS: Leptin exerts a plethora of metabolic effects on various tissues including suppressing production of glucagon and corticosterone, increasing glucose uptake, and inhibiting hepatic glucose output. A more in-depth understanding of the mechanisms of the glucose-lowering actions of leptin may reveal new strategies to treat metabolic disorders.
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spelling pubmed-56057342017-09-26 The glucoregulatory actions of leptin D'souza, Anna M. Neumann, Ursula H. Glavas, Maria M. Kieffer, Timothy J. Mol Metab Review BACKGROUND: The hormone leptin is an important regulator of metabolic homeostasis, able to inhibit food intake and increase energy expenditure. Leptin can also independently lower blood glucose levels, particularly in hyperglycemic models of leptin or insulin deficiency. Despite significant efforts and relevance to diabetes, the mechanisms by which leptin acts to regulate blood glucose levels are not fully understood. SCOPE OF REVIEW: Here we assess literature relevant to the glucose lowering effects of leptin. Leptin receptors are widely expressed in multiple cell types, and we describe both peripheral and central effects of leptin that may be involved in lowering blood glucose. In addition, we summarize the potential clinical application of leptin in regulating glucose homeostasis. MAJOR CONCLUSIONS: Leptin exerts a plethora of metabolic effects on various tissues including suppressing production of glucagon and corticosterone, increasing glucose uptake, and inhibiting hepatic glucose output. A more in-depth understanding of the mechanisms of the glucose-lowering actions of leptin may reveal new strategies to treat metabolic disorders. Elsevier 2017-05-04 /pmc/articles/PMC5605734/ /pubmed/28951828 http://dx.doi.org/10.1016/j.molmet.2017.04.011 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
D'souza, Anna M.
Neumann, Ursula H.
Glavas, Maria M.
Kieffer, Timothy J.
The glucoregulatory actions of leptin
title The glucoregulatory actions of leptin
title_full The glucoregulatory actions of leptin
title_fullStr The glucoregulatory actions of leptin
title_full_unstemmed The glucoregulatory actions of leptin
title_short The glucoregulatory actions of leptin
title_sort glucoregulatory actions of leptin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605734/
https://www.ncbi.nlm.nih.gov/pubmed/28951828
http://dx.doi.org/10.1016/j.molmet.2017.04.011
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