Enantioselective copper catalysed, direct functionalisation of allenes via allyl copper intermediates

The direct functionalisation of allenes under copper catalysis enables efficient access to enantioenriched, densely functionalised molecules. In this review we explore the breadth and depth of a versatile reaction manifold, which involves the element-cupration of allenes to generate allyl copper int...

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Detalles Bibliográficos
Autores principales: Pulis, Alexander P., Yeung, Kay, Procter, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605774/
https://www.ncbi.nlm.nih.gov/pubmed/28959423
http://dx.doi.org/10.1039/c7sc01968h
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author Pulis, Alexander P.
Yeung, Kay
Procter, David J.
author_facet Pulis, Alexander P.
Yeung, Kay
Procter, David J.
author_sort Pulis, Alexander P.
collection PubMed
description The direct functionalisation of allenes under copper catalysis enables efficient access to enantioenriched, densely functionalised molecules. In this review we explore the breadth and depth of a versatile reaction manifold, which involves the element-cupration of allenes to generate allyl copper intermediates that are subsequently coupled with diverse arrays of electrophiles.
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spelling pubmed-56057742017-09-28 Enantioselective copper catalysed, direct functionalisation of allenes via allyl copper intermediates Pulis, Alexander P. Yeung, Kay Procter, David J. Chem Sci Chemistry The direct functionalisation of allenes under copper catalysis enables efficient access to enantioenriched, densely functionalised molecules. In this review we explore the breadth and depth of a versatile reaction manifold, which involves the element-cupration of allenes to generate allyl copper intermediates that are subsequently coupled with diverse arrays of electrophiles. Royal Society of Chemistry 2017-08-01 2017-06-08 /pmc/articles/PMC5605774/ /pubmed/28959423 http://dx.doi.org/10.1039/c7sc01968h Text en This journal is © The Royal Society of Chemistry 2017 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Pulis, Alexander P.
Yeung, Kay
Procter, David J.
Enantioselective copper catalysed, direct functionalisation of allenes via allyl copper intermediates
title Enantioselective copper catalysed, direct functionalisation of allenes via allyl copper intermediates
title_full Enantioselective copper catalysed, direct functionalisation of allenes via allyl copper intermediates
title_fullStr Enantioselective copper catalysed, direct functionalisation of allenes via allyl copper intermediates
title_full_unstemmed Enantioselective copper catalysed, direct functionalisation of allenes via allyl copper intermediates
title_short Enantioselective copper catalysed, direct functionalisation of allenes via allyl copper intermediates
title_sort enantioselective copper catalysed, direct functionalisation of allenes via allyl copper intermediates
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605774/
https://www.ncbi.nlm.nih.gov/pubmed/28959423
http://dx.doi.org/10.1039/c7sc01968h
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AT procterdavidj enantioselectivecoppercatalyseddirectfunctionalisationofallenesviaallylcopperintermediates

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