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Down but Not Out: The Consequences of Pretangle Tau in the Locus Coeruleus

Degeneration of locus coeruleus (LC) is an underappreciated hallmark of Alzheimer's disease (AD). The LC is the main source of norepinephrine (NE) in the forebrain, and its degeneration is highly correlated with cognitive impairment and amyloid-beta (Aβ) and tangle pathology. Hyperphosphorylate...

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Detalles Bibliográficos
Autores principales:	Chalermpalanupap, Termpanit, Weinshenker, David, Rorabaugh, Jacki M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605916/ https://www.ncbi.nlm.nih.gov/pubmed/29038736 http://dx.doi.org/10.1155/2017/7829507

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