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Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns
Antibiotic resistance forms a serious threat to the health of hospitalised patients, rendering otherwise treatable bacterial infections potentially life-threatening. A thorough understanding of the mechanisms by which resistance spreads between patients in different hospitals is required in order to...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Microbiology Society
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605955/ https://www.ncbi.nlm.nih.gov/pubmed/29026654 http://dx.doi.org/10.1099/mgen.0.000113 |
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author | Donker, Tjibbe Reuter, Sandra Scriberras, James Reynolds, Rosy Brown, Nicholas M. Török, M. Estée James, Richard Network, East of England Microbiology Research Aanensen, David M. Bentley, Stephen D. Holden, Matthew T. G. Parkhill, Julian Spratt, Brian G. Peacock, Sharon J. Feil, Edward J. Grundmann, Hajo |
author_facet | Donker, Tjibbe Reuter, Sandra Scriberras, James Reynolds, Rosy Brown, Nicholas M. Török, M. Estée James, Richard Network, East of England Microbiology Research Aanensen, David M. Bentley, Stephen D. Holden, Matthew T. G. Parkhill, Julian Spratt, Brian G. Peacock, Sharon J. Feil, Edward J. Grundmann, Hajo |
author_sort | Donker, Tjibbe |
collection | PubMed |
description | Antibiotic resistance forms a serious threat to the health of hospitalised patients, rendering otherwise treatable bacterial infections potentially life-threatening. A thorough understanding of the mechanisms by which resistance spreads between patients in different hospitals is required in order to design effective control strategies. We measured the differences between bacterial populations of 52 hospitals in the United Kingdom and Ireland, using whole-genome sequences from 1085 MRSA clonal complex 22 isolates collected between 1998 and 2012. The genetic differences between bacterial populations were compared with the number of patients transferred between hospitals and their regional structure. The MRSA populations within single hospitals, regions and countries were genetically distinct from the rest of the bacterial population at each of these levels. Hospitals from the same patient referral regions showed more similar MRSA populations, as did hospitals sharing many patients. Furthermore, the bacterial populations from different time-periods within the same hospital were generally more similar to each other than contemporaneous bacterial populations from different hospitals. We conclude that, while a large part of the dispersal and expansion of MRSA takes place among patients seeking care in single hospitals, inter-hospital spread of resistant bacteria is by no means a rare occurrence. Hospitals are exposed to constant introductions of MRSA on a number of levels: (1) most MRSA is received from hospitals that directly transfer large numbers of patients, while (2) fewer introductions happen between regions or (3) across national borders, reflecting lower numbers of transferred patients. A joint coordinated control effort between hospitals, is therefore paramount for the national control of MRSA, antibiotic-resistant bacteria and other hospital-associated pathogens. |
format | Online Article Text |
id | pubmed-5605955 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Microbiology Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-56059552017-10-12 Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns Donker, Tjibbe Reuter, Sandra Scriberras, James Reynolds, Rosy Brown, Nicholas M. Török, M. Estée James, Richard Network, East of England Microbiology Research Aanensen, David M. Bentley, Stephen D. Holden, Matthew T. G. Parkhill, Julian Spratt, Brian G. Peacock, Sharon J. Feil, Edward J. Grundmann, Hajo Microb Genom Research Article Antibiotic resistance forms a serious threat to the health of hospitalised patients, rendering otherwise treatable bacterial infections potentially life-threatening. A thorough understanding of the mechanisms by which resistance spreads between patients in different hospitals is required in order to design effective control strategies. We measured the differences between bacterial populations of 52 hospitals in the United Kingdom and Ireland, using whole-genome sequences from 1085 MRSA clonal complex 22 isolates collected between 1998 and 2012. The genetic differences between bacterial populations were compared with the number of patients transferred between hospitals and their regional structure. The MRSA populations within single hospitals, regions and countries were genetically distinct from the rest of the bacterial population at each of these levels. Hospitals from the same patient referral regions showed more similar MRSA populations, as did hospitals sharing many patients. Furthermore, the bacterial populations from different time-periods within the same hospital were generally more similar to each other than contemporaneous bacterial populations from different hospitals. We conclude that, while a large part of the dispersal and expansion of MRSA takes place among patients seeking care in single hospitals, inter-hospital spread of resistant bacteria is by no means a rare occurrence. Hospitals are exposed to constant introductions of MRSA on a number of levels: (1) most MRSA is received from hospitals that directly transfer large numbers of patients, while (2) fewer introductions happen between regions or (3) across national borders, reflecting lower numbers of transferred patients. A joint coordinated control effort between hospitals, is therefore paramount for the national control of MRSA, antibiotic-resistant bacteria and other hospital-associated pathogens. Microbiology Society 2017-07-04 /pmc/articles/PMC5605955/ /pubmed/29026654 http://dx.doi.org/10.1099/mgen.0.000113 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Donker, Tjibbe Reuter, Sandra Scriberras, James Reynolds, Rosy Brown, Nicholas M. Török, M. Estée James, Richard Network, East of England Microbiology Research Aanensen, David M. Bentley, Stephen D. Holden, Matthew T. G. Parkhill, Julian Spratt, Brian G. Peacock, Sharon J. Feil, Edward J. Grundmann, Hajo Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns |
title | Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns |
title_full | Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns |
title_fullStr | Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns |
title_full_unstemmed | Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns |
title_short | Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns |
title_sort | population genetic structuring of methicillin-resistant staphylococcus aureus clone emrsa-15 within uk reflects patient referral patterns |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605955/ https://www.ncbi.nlm.nih.gov/pubmed/29026654 http://dx.doi.org/10.1099/mgen.0.000113 |
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