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Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer

Colorectal cancer (CRC) is the fourth most frequent type of malignancy in the world. Metastasis accounts for >90% mortalities in patients with CRC. The metastasis-associated in colon cancer 1 (MACC1) gene has been identified as a novel biomarker for the prediction of metastasis and disease progno...

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Autores principales: Li, He, Chen, Yi-Xin, Wen, Jia-Gen, Zhou, Hong-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605967/
https://www.ncbi.nlm.nih.gov/pubmed/28943898
http://dx.doi.org/10.3892/ol.2017.6670
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author Li, He
Chen, Yi-Xin
Wen, Jia-Gen
Zhou, Hong-Hao
author_facet Li, He
Chen, Yi-Xin
Wen, Jia-Gen
Zhou, Hong-Hao
author_sort Li, He
collection PubMed
description Colorectal cancer (CRC) is the fourth most frequent type of malignancy in the world. Metastasis accounts for >90% mortalities in patients with CRC. The metastasis-associated in colon cancer 1 (MACC1) gene has been identified as a novel biomarker for the prediction of metastasis and disease prognosis, particularly for patients with early-stage disease. Previous clinical studies demonstrated that MACC1 expression and polymorphisms in CRC tissues were indicators of metastasis, and that circulating transcripts in plasma were also significantly associated with the survival of patients. The present review describes the use of MACC1 beyond its utility in the clinic. By elucidating the upstream and downstream signal pathways of MACC1, the well-known mechanisms of MACC1-mediated cell proliferation, invasion, migration and epithelial-mesenchymal transition (EMT) are summarized, as well as the potential signaling pathways. Furthermore, the underlying mechanisms by which the overexpression of MACC1 causes cisplatin resistance are emphasized.
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spelling pubmed-56059672017-09-22 Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer Li, He Chen, Yi-Xin Wen, Jia-Gen Zhou, Hong-Hao Oncol Lett Review Colorectal cancer (CRC) is the fourth most frequent type of malignancy in the world. Metastasis accounts for >90% mortalities in patients with CRC. The metastasis-associated in colon cancer 1 (MACC1) gene has been identified as a novel biomarker for the prediction of metastasis and disease prognosis, particularly for patients with early-stage disease. Previous clinical studies demonstrated that MACC1 expression and polymorphisms in CRC tissues were indicators of metastasis, and that circulating transcripts in plasma were also significantly associated with the survival of patients. The present review describes the use of MACC1 beyond its utility in the clinic. By elucidating the upstream and downstream signal pathways of MACC1, the well-known mechanisms of MACC1-mediated cell proliferation, invasion, migration and epithelial-mesenchymal transition (EMT) are summarized, as well as the potential signaling pathways. Furthermore, the underlying mechanisms by which the overexpression of MACC1 causes cisplatin resistance are emphasized. D.A. Spandidos 2017-10 2017-07-26 /pmc/articles/PMC5605967/ /pubmed/28943898 http://dx.doi.org/10.3892/ol.2017.6670 Text en Copyright: © Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Li, He
Chen, Yi-Xin
Wen, Jia-Gen
Zhou, Hong-Hao
Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer
title Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer
title_full Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer
title_fullStr Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer
title_full_unstemmed Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer
title_short Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer
title_sort metastasis-associated in colon cancer 1: a promising biomarker for the metastasis and prognosis of colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605967/
https://www.ncbi.nlm.nih.gov/pubmed/28943898
http://dx.doi.org/10.3892/ol.2017.6670
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