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TWEAK/Fn14 Activation Participates in Skin Inflammation
Tumor necrosis factor- (TNF-) like weak inducer of apoptosis (TWEAK) participates in multiple biological activities via binding to its sole receptor—fibroblast growth factor-inducible 14 (Fn14). The TWEAK/Fn14 signaling pathway is activated in skin inflammation and modulates the inflammatory respons...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606047/ https://www.ncbi.nlm.nih.gov/pubmed/29038621 http://dx.doi.org/10.1155/2017/6746870 |
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author | Liu, Qilu Xiao, Shengxiang Xia, Yumin |
author_facet | Liu, Qilu Xiao, Shengxiang Xia, Yumin |
author_sort | Liu, Qilu |
collection | PubMed |
description | Tumor necrosis factor- (TNF-) like weak inducer of apoptosis (TWEAK) participates in multiple biological activities via binding to its sole receptor—fibroblast growth factor-inducible 14 (Fn14). The TWEAK/Fn14 signaling pathway is activated in skin inflammation and modulates the inflammatory responses of keratinocytes by activating nuclear factor-κB signals and enhancing the production of several cytokines, including interleukins, monocyte chemotactic protein-1, RANTES (regulated on activation, normal T cell expressed and secreted), and interferon gamma-induced protein 10. Mild or transient TWEAK/Fn14 activation contributes to tissular repair and regeneration while excessive or persistent TWEAK/Fn14 signals may lead to severe inflammatory infiltration and tissue damage. TWEAK also regulates cell fate of keratinocytes, involving the function of Fn14-TNF receptor-associated factor-TNF receptor axis. By recruiting inflammatory cells, promoting cytokine production, and regulating cell fate, TWEAK/Fn14 activation plays a pivotal role in the pathogenesis of various skin disorders, such as psoriasis, atopic dermatitis, cutaneous vasculitis, human papillomavirus infection and related skin tumors, and cutaneous autoimmune diseases. Therefore, the TWEAK/Fn14 pathway may be a potential target for the development of novel therapeutics for skin inflammatory diseases. |
format | Online Article Text |
id | pubmed-5606047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-56060472017-10-16 TWEAK/Fn14 Activation Participates in Skin Inflammation Liu, Qilu Xiao, Shengxiang Xia, Yumin Mediators Inflamm Review Article Tumor necrosis factor- (TNF-) like weak inducer of apoptosis (TWEAK) participates in multiple biological activities via binding to its sole receptor—fibroblast growth factor-inducible 14 (Fn14). The TWEAK/Fn14 signaling pathway is activated in skin inflammation and modulates the inflammatory responses of keratinocytes by activating nuclear factor-κB signals and enhancing the production of several cytokines, including interleukins, monocyte chemotactic protein-1, RANTES (regulated on activation, normal T cell expressed and secreted), and interferon gamma-induced protein 10. Mild or transient TWEAK/Fn14 activation contributes to tissular repair and regeneration while excessive or persistent TWEAK/Fn14 signals may lead to severe inflammatory infiltration and tissue damage. TWEAK also regulates cell fate of keratinocytes, involving the function of Fn14-TNF receptor-associated factor-TNF receptor axis. By recruiting inflammatory cells, promoting cytokine production, and regulating cell fate, TWEAK/Fn14 activation plays a pivotal role in the pathogenesis of various skin disorders, such as psoriasis, atopic dermatitis, cutaneous vasculitis, human papillomavirus infection and related skin tumors, and cutaneous autoimmune diseases. Therefore, the TWEAK/Fn14 pathway may be a potential target for the development of novel therapeutics for skin inflammatory diseases. Hindawi 2017 2017-09-06 /pmc/articles/PMC5606047/ /pubmed/29038621 http://dx.doi.org/10.1155/2017/6746870 Text en Copyright © 2017 Qilu Liu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Liu, Qilu Xiao, Shengxiang Xia, Yumin TWEAK/Fn14 Activation Participates in Skin Inflammation |
title | TWEAK/Fn14 Activation Participates in Skin Inflammation |
title_full | TWEAK/Fn14 Activation Participates in Skin Inflammation |
title_fullStr | TWEAK/Fn14 Activation Participates in Skin Inflammation |
title_full_unstemmed | TWEAK/Fn14 Activation Participates in Skin Inflammation |
title_short | TWEAK/Fn14 Activation Participates in Skin Inflammation |
title_sort | tweak/fn14 activation participates in skin inflammation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606047/ https://www.ncbi.nlm.nih.gov/pubmed/29038621 http://dx.doi.org/10.1155/2017/6746870 |
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