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TWEAK/Fn14 Activation Participates in Skin Inflammation

Tumor necrosis factor- (TNF-) like weak inducer of apoptosis (TWEAK) participates in multiple biological activities via binding to its sole receptor—fibroblast growth factor-inducible 14 (Fn14). The TWEAK/Fn14 signaling pathway is activated in skin inflammation and modulates the inflammatory respons...

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Autores principales: Liu, Qilu, Xiao, Shengxiang, Xia, Yumin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606047/
https://www.ncbi.nlm.nih.gov/pubmed/29038621
http://dx.doi.org/10.1155/2017/6746870
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author Liu, Qilu
Xiao, Shengxiang
Xia, Yumin
author_facet Liu, Qilu
Xiao, Shengxiang
Xia, Yumin
author_sort Liu, Qilu
collection PubMed
description Tumor necrosis factor- (TNF-) like weak inducer of apoptosis (TWEAK) participates in multiple biological activities via binding to its sole receptor—fibroblast growth factor-inducible 14 (Fn14). The TWEAK/Fn14 signaling pathway is activated in skin inflammation and modulates the inflammatory responses of keratinocytes by activating nuclear factor-κB signals and enhancing the production of several cytokines, including interleukins, monocyte chemotactic protein-1, RANTES (regulated on activation, normal T cell expressed and secreted), and interferon gamma-induced protein 10. Mild or transient TWEAK/Fn14 activation contributes to tissular repair and regeneration while excessive or persistent TWEAK/Fn14 signals may lead to severe inflammatory infiltration and tissue damage. TWEAK also regulates cell fate of keratinocytes, involving the function of Fn14-TNF receptor-associated factor-TNF receptor axis. By recruiting inflammatory cells, promoting cytokine production, and regulating cell fate, TWEAK/Fn14 activation plays a pivotal role in the pathogenesis of various skin disorders, such as psoriasis, atopic dermatitis, cutaneous vasculitis, human papillomavirus infection and related skin tumors, and cutaneous autoimmune diseases. Therefore, the TWEAK/Fn14 pathway may be a potential target for the development of novel therapeutics for skin inflammatory diseases.
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spelling pubmed-56060472017-10-16 TWEAK/Fn14 Activation Participates in Skin Inflammation Liu, Qilu Xiao, Shengxiang Xia, Yumin Mediators Inflamm Review Article Tumor necrosis factor- (TNF-) like weak inducer of apoptosis (TWEAK) participates in multiple biological activities via binding to its sole receptor—fibroblast growth factor-inducible 14 (Fn14). The TWEAK/Fn14 signaling pathway is activated in skin inflammation and modulates the inflammatory responses of keratinocytes by activating nuclear factor-κB signals and enhancing the production of several cytokines, including interleukins, monocyte chemotactic protein-1, RANTES (regulated on activation, normal T cell expressed and secreted), and interferon gamma-induced protein 10. Mild or transient TWEAK/Fn14 activation contributes to tissular repair and regeneration while excessive or persistent TWEAK/Fn14 signals may lead to severe inflammatory infiltration and tissue damage. TWEAK also regulates cell fate of keratinocytes, involving the function of Fn14-TNF receptor-associated factor-TNF receptor axis. By recruiting inflammatory cells, promoting cytokine production, and regulating cell fate, TWEAK/Fn14 activation plays a pivotal role in the pathogenesis of various skin disorders, such as psoriasis, atopic dermatitis, cutaneous vasculitis, human papillomavirus infection and related skin tumors, and cutaneous autoimmune diseases. Therefore, the TWEAK/Fn14 pathway may be a potential target for the development of novel therapeutics for skin inflammatory diseases. Hindawi 2017 2017-09-06 /pmc/articles/PMC5606047/ /pubmed/29038621 http://dx.doi.org/10.1155/2017/6746870 Text en Copyright © 2017 Qilu Liu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Liu, Qilu
Xiao, Shengxiang
Xia, Yumin
TWEAK/Fn14 Activation Participates in Skin Inflammation
title TWEAK/Fn14 Activation Participates in Skin Inflammation
title_full TWEAK/Fn14 Activation Participates in Skin Inflammation
title_fullStr TWEAK/Fn14 Activation Participates in Skin Inflammation
title_full_unstemmed TWEAK/Fn14 Activation Participates in Skin Inflammation
title_short TWEAK/Fn14 Activation Participates in Skin Inflammation
title_sort tweak/fn14 activation participates in skin inflammation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606047/
https://www.ncbi.nlm.nih.gov/pubmed/29038621
http://dx.doi.org/10.1155/2017/6746870
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