Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

Gene silencing by heterochromatin is proposed to occur in part from the ability of HP1 proteins to spread across large regions of the genome, compact the underlying chromatin and recruit repressive activities(1–3). Here we identify a new property of the human HP1α protein: the ability to form phase-...

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Detalles Bibliográficos
Autores principales: Larson, Adam G., Elnatan, Daniel, Keenen, Madeline M., Trnka, Michael J., Johnston, Jonathan B., Burlingame, Alma L., Agard, David A., Redding, Sy, Narlikar, Geeta J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606208/
https://www.ncbi.nlm.nih.gov/pubmed/28636604
http://dx.doi.org/10.1038/nature22822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606208/
https://www.ncbi.nlm.nih.gov/pubmed/28636604
http://dx.doi.org/10.1038/nature22822

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