Unusual case of splenic sarcoidosis without morphological lesions detected by PET-CT in a patient with breast cancer: functional imaging between pitfalls and therapeutic guide

A 60-year-old woman under treatment with letrozole for metastatic breast cancer underwent (18)F-FDG PET-CT for restaging. A new widespread intense splenic FDG uptake without nodular lesions and multiple FDG-avid mediastinal and abdominal nodes were observed. Based on these findings, a nodal and tran...

Descripción completa

Detalles Bibliográficos
Autores principales: Paone, Gaetano, Di Lascio, Simona, Azzola, Andrea, Mazzucchelli, Luca, Pagani, Olivia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606293/
https://www.ncbi.nlm.nih.gov/pubmed/28955402
http://dx.doi.org/10.3332/ecancer.2017.766
_version_ 1783265122625519616
author Paone, Gaetano
Di Lascio, Simona
Azzola, Andrea
Mazzucchelli, Luca
Pagani, Olivia
author_facet Paone, Gaetano
Di Lascio, Simona
Azzola, Andrea
Mazzucchelli, Luca
Pagani, Olivia
author_sort Paone, Gaetano
collection PubMed
description A 60-year-old woman under treatment with letrozole for metastatic breast cancer underwent (18)F-FDG PET-CT for restaging. A new widespread intense splenic FDG uptake without nodular lesions and multiple FDG-avid mediastinal and abdominal nodes were observed. Based on these findings, a nodal and transbronchial lung biopsy was performed. Histological results were compatible with sarcoidosis. The patient began steroid treatment and 6 weeks after a PET-CT showed normalisation of both splenic and nodal uptake. In our case, (18)F-FDG PET-CT has been useful in detecting a rare case of splenic sarcoidosis without typical nodular lesions on CT images, impacting the patient’s treatment and prognosis.
format Online
Article
Text
id pubmed-5606293
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Cancer Intelligence
record_format MEDLINE/PubMed
spelling pubmed-56062932017-09-27 Unusual case of splenic sarcoidosis without morphological lesions detected by PET-CT in a patient with breast cancer: functional imaging between pitfalls and therapeutic guide Paone, Gaetano Di Lascio, Simona Azzola, Andrea Mazzucchelli, Luca Pagani, Olivia Ecancermedicalscience Case Report A 60-year-old woman under treatment with letrozole for metastatic breast cancer underwent (18)F-FDG PET-CT for restaging. A new widespread intense splenic FDG uptake without nodular lesions and multiple FDG-avid mediastinal and abdominal nodes were observed. Based on these findings, a nodal and transbronchial lung biopsy was performed. Histological results were compatible with sarcoidosis. The patient began steroid treatment and 6 weeks after a PET-CT showed normalisation of both splenic and nodal uptake. In our case, (18)F-FDG PET-CT has been useful in detecting a rare case of splenic sarcoidosis without typical nodular lesions on CT images, impacting the patient’s treatment and prognosis. Cancer Intelligence 2017-09-08 /pmc/articles/PMC5606293/ /pubmed/28955402 http://dx.doi.org/10.3332/ecancer.2017.766 Text en © the authors; licensee ecancermedicalscience. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Paone, Gaetano
Di Lascio, Simona
Azzola, Andrea
Mazzucchelli, Luca
Pagani, Olivia
Unusual case of splenic sarcoidosis without morphological lesions detected by PET-CT in a patient with breast cancer: functional imaging between pitfalls and therapeutic guide
title Unusual case of splenic sarcoidosis without morphological lesions detected by PET-CT in a patient with breast cancer: functional imaging between pitfalls and therapeutic guide
title_full Unusual case of splenic sarcoidosis without morphological lesions detected by PET-CT in a patient with breast cancer: functional imaging between pitfalls and therapeutic guide
title_fullStr Unusual case of splenic sarcoidosis without morphological lesions detected by PET-CT in a patient with breast cancer: functional imaging between pitfalls and therapeutic guide
title_full_unstemmed Unusual case of splenic sarcoidosis without morphological lesions detected by PET-CT in a patient with breast cancer: functional imaging between pitfalls and therapeutic guide
title_short Unusual case of splenic sarcoidosis without morphological lesions detected by PET-CT in a patient with breast cancer: functional imaging between pitfalls and therapeutic guide
title_sort unusual case of splenic sarcoidosis without morphological lesions detected by pet-ct in a patient with breast cancer: functional imaging between pitfalls and therapeutic guide
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606293/
https://www.ncbi.nlm.nih.gov/pubmed/28955402
http://dx.doi.org/10.3332/ecancer.2017.766
work_keys_str_mv AT paonegaetano unusualcaseofsplenicsarcoidosiswithoutmorphologicallesionsdetectedbypetctinapatientwithbreastcancerfunctionalimagingbetweenpitfallsandtherapeuticguide
AT dilasciosimona unusualcaseofsplenicsarcoidosiswithoutmorphologicallesionsdetectedbypetctinapatientwithbreastcancerfunctionalimagingbetweenpitfallsandtherapeuticguide
AT azzolaandrea unusualcaseofsplenicsarcoidosiswithoutmorphologicallesionsdetectedbypetctinapatientwithbreastcancerfunctionalimagingbetweenpitfallsandtherapeuticguide
AT mazzucchelliluca unusualcaseofsplenicsarcoidosiswithoutmorphologicallesionsdetectedbypetctinapatientwithbreastcancerfunctionalimagingbetweenpitfallsandtherapeuticguide
AT paganiolivia unusualcaseofsplenicsarcoidosiswithoutmorphologicallesionsdetectedbypetctinapatientwithbreastcancerfunctionalimagingbetweenpitfallsandtherapeuticguide

Ejemplares similares