Cargando…

EDCs Mixtures: A Stealthy Hazard for Human Health?

Endocrine disrupting chemicals (EDCs) are exogenous chemicals that may occur naturally (e.g., phytoestrogens), while others are industrial substances and plasticizers commonly utilized worldwide to which human exposure, particularly at low-doses, is omnipresent, persistent and occurs in complex mixt...

Descripción completa

Detalles Bibliográficos
Autores principales: Ribeiro, Edna, Ladeira, Carina, Viegas, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606671/
https://www.ncbi.nlm.nih.gov/pubmed/29051438
http://dx.doi.org/10.3390/toxics5010005
_version_ 1783265154183462912
author Ribeiro, Edna
Ladeira, Carina
Viegas, Susana
author_facet Ribeiro, Edna
Ladeira, Carina
Viegas, Susana
author_sort Ribeiro, Edna
collection PubMed
description Endocrine disrupting chemicals (EDCs) are exogenous chemicals that may occur naturally (e.g., phytoestrogens), while others are industrial substances and plasticizers commonly utilized worldwide to which human exposure, particularly at low-doses, is omnipresent, persistent and occurs in complex mixtures. EDCs can interfere with/or mimic estrogenic hormones and, consequently, can simultaneously trigger diverse signaling pathways which result in diverse and divergent biological responses. Additionally, EDCs can also bioaccumulate in lipid compartments of the organism forming a mixed “body burden” of contaminants. Although the independent action of chemicals has been considered the main principle in EDCs mixture toxicity, recent studies have demonstrated that numerous effects cannot be predicted when analyzing single compounds independently. Co-exposure to these agents, particularly in critical windows of exposure, may induce hazardous health effects potentially associated with a complex “body burden” of different origins. Here, we performed an exhaustive review of the available literature regarding EDCs mixtures exposure, toxicity mechanisms and effects, particularly at the most vulnerable human life stages. Although the assessment of potential risks to human health due to exposure to EDCs mixtures is a major topic for consumer safety, information regarding effective mixtures effects is still scarce.
format Online
Article
Text
id pubmed-5606671
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-56066712017-10-18 EDCs Mixtures: A Stealthy Hazard for Human Health? Ribeiro, Edna Ladeira, Carina Viegas, Susana Toxics Review Endocrine disrupting chemicals (EDCs) are exogenous chemicals that may occur naturally (e.g., phytoestrogens), while others are industrial substances and plasticizers commonly utilized worldwide to which human exposure, particularly at low-doses, is omnipresent, persistent and occurs in complex mixtures. EDCs can interfere with/or mimic estrogenic hormones and, consequently, can simultaneously trigger diverse signaling pathways which result in diverse and divergent biological responses. Additionally, EDCs can also bioaccumulate in lipid compartments of the organism forming a mixed “body burden” of contaminants. Although the independent action of chemicals has been considered the main principle in EDCs mixture toxicity, recent studies have demonstrated that numerous effects cannot be predicted when analyzing single compounds independently. Co-exposure to these agents, particularly in critical windows of exposure, may induce hazardous health effects potentially associated with a complex “body burden” of different origins. Here, we performed an exhaustive review of the available literature regarding EDCs mixtures exposure, toxicity mechanisms and effects, particularly at the most vulnerable human life stages. Although the assessment of potential risks to human health due to exposure to EDCs mixtures is a major topic for consumer safety, information regarding effective mixtures effects is still scarce. MDPI 2017-02-07 /pmc/articles/PMC5606671/ /pubmed/29051438 http://dx.doi.org/10.3390/toxics5010005 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ribeiro, Edna
Ladeira, Carina
Viegas, Susana
EDCs Mixtures: A Stealthy Hazard for Human Health?
title EDCs Mixtures: A Stealthy Hazard for Human Health?
title_full EDCs Mixtures: A Stealthy Hazard for Human Health?
title_fullStr EDCs Mixtures: A Stealthy Hazard for Human Health?
title_full_unstemmed EDCs Mixtures: A Stealthy Hazard for Human Health?
title_short EDCs Mixtures: A Stealthy Hazard for Human Health?
title_sort edcs mixtures: a stealthy hazard for human health?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606671/
https://www.ncbi.nlm.nih.gov/pubmed/29051438
http://dx.doi.org/10.3390/toxics5010005
work_keys_str_mv AT ribeiroedna edcsmixturesastealthyhazardforhumanhealth
AT ladeiracarina edcsmixturesastealthyhazardforhumanhealth
AT viegassusana edcsmixturesastealthyhazardforhumanhealth