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Learning induces the translin/trax RNase complex to express activin receptors for persistent memory

Long-lasting forms of synaptic plasticity and memory require de novo protein synthesis. Yet, how learning triggers this process to form memory is unclear. Translin/trax is a candidate to drive this learning-induced memory mechanism by suppressing microRNA-mediated translational silencing at activate...

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Autores principales: Park, Alan Jung, Havekes, Robbert, Fu, Xiuping, Hansen, Rolf, Tudor, Jennifer C, Peixoto, Lucia, Li, Zhi, Wu, Yen-Ching, Poplawski, Shane G, Baraban, Jay M, Abel, Ted
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606845/
https://www.ncbi.nlm.nih.gov/pubmed/28927503
http://dx.doi.org/10.7554/eLife.27872
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author Park, Alan Jung
Havekes, Robbert
Fu, Xiuping
Hansen, Rolf
Tudor, Jennifer C
Peixoto, Lucia
Li, Zhi
Wu, Yen-Ching
Poplawski, Shane G
Baraban, Jay M
Abel, Ted
author_facet Park, Alan Jung
Havekes, Robbert
Fu, Xiuping
Hansen, Rolf
Tudor, Jennifer C
Peixoto, Lucia
Li, Zhi
Wu, Yen-Ching
Poplawski, Shane G
Baraban, Jay M
Abel, Ted
author_sort Park, Alan Jung
collection PubMed
description Long-lasting forms of synaptic plasticity and memory require de novo protein synthesis. Yet, how learning triggers this process to form memory is unclear. Translin/trax is a candidate to drive this learning-induced memory mechanism by suppressing microRNA-mediated translational silencing at activated synapses. We find that mice lacking translin/trax display defects in synaptic tagging, which requires protein synthesis at activated synapses, and long-term memory. Hippocampal samples harvested from these mice following learning show increases in several disease-related microRNAs targeting the activin A receptor type 1C (ACVR1C), a component of the transforming growth factor-β receptor superfamily. Furthermore, the absence of translin/trax abolishes synaptic upregulation of ACVR1C protein after learning. Finally, synaptic tagging and long-term memory deficits in mice lacking translin/trax are mimicked by ACVR1C inhibition. Thus, we define a new memory mechanism by which learning reverses microRNA-mediated silencing of the novel plasticity protein ACVR1C via translin/trax.
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spelling pubmed-56068452017-09-25 Learning induces the translin/trax RNase complex to express activin receptors for persistent memory Park, Alan Jung Havekes, Robbert Fu, Xiuping Hansen, Rolf Tudor, Jennifer C Peixoto, Lucia Li, Zhi Wu, Yen-Ching Poplawski, Shane G Baraban, Jay M Abel, Ted eLife Neuroscience Long-lasting forms of synaptic plasticity and memory require de novo protein synthesis. Yet, how learning triggers this process to form memory is unclear. Translin/trax is a candidate to drive this learning-induced memory mechanism by suppressing microRNA-mediated translational silencing at activated synapses. We find that mice lacking translin/trax display defects in synaptic tagging, which requires protein synthesis at activated synapses, and long-term memory. Hippocampal samples harvested from these mice following learning show increases in several disease-related microRNAs targeting the activin A receptor type 1C (ACVR1C), a component of the transforming growth factor-β receptor superfamily. Furthermore, the absence of translin/trax abolishes synaptic upregulation of ACVR1C protein after learning. Finally, synaptic tagging and long-term memory deficits in mice lacking translin/trax are mimicked by ACVR1C inhibition. Thus, we define a new memory mechanism by which learning reverses microRNA-mediated silencing of the novel plasticity protein ACVR1C via translin/trax. eLife Sciences Publications, Ltd 2017-09-20 /pmc/articles/PMC5606845/ /pubmed/28927503 http://dx.doi.org/10.7554/eLife.27872 Text en © 2017, Park et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Park, Alan Jung
Havekes, Robbert
Fu, Xiuping
Hansen, Rolf
Tudor, Jennifer C
Peixoto, Lucia
Li, Zhi
Wu, Yen-Ching
Poplawski, Shane G
Baraban, Jay M
Abel, Ted
Learning induces the translin/trax RNase complex to express activin receptors for persistent memory
title Learning induces the translin/trax RNase complex to express activin receptors for persistent memory
title_full Learning induces the translin/trax RNase complex to express activin receptors for persistent memory
title_fullStr Learning induces the translin/trax RNase complex to express activin receptors for persistent memory
title_full_unstemmed Learning induces the translin/trax RNase complex to express activin receptors for persistent memory
title_short Learning induces the translin/trax RNase complex to express activin receptors for persistent memory
title_sort learning induces the translin/trax rnase complex to express activin receptors for persistent memory
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606845/
https://www.ncbi.nlm.nih.gov/pubmed/28927503
http://dx.doi.org/10.7554/eLife.27872
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