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Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior
A sudden aversive event produces escape behaviors, an innate response essential for survival in virtually all-animal species. Nuclei including the lateral habenula (LHb), the lateral hypothalamus (LH), and the midbrain are not only reciprocally connected, but also respond to negative events contribu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606847/ https://www.ncbi.nlm.nih.gov/pubmed/28871962 http://dx.doi.org/10.7554/eLife.30697 |
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author | Lecca, Salvatore Meye, Frank Julius Trusel, Massimo Tchenio, Anna Harris, Julia Schwarz, Martin Karl Burdakov, Denis Georges, Francois Mameli, Manuel |
author_facet | Lecca, Salvatore Meye, Frank Julius Trusel, Massimo Tchenio, Anna Harris, Julia Schwarz, Martin Karl Burdakov, Denis Georges, Francois Mameli, Manuel |
author_sort | Lecca, Salvatore |
collection | PubMed |
description | A sudden aversive event produces escape behaviors, an innate response essential for survival in virtually all-animal species. Nuclei including the lateral habenula (LHb), the lateral hypothalamus (LH), and the midbrain are not only reciprocally connected, but also respond to negative events contributing to goal-directed behaviors. However, whether aversion encoding requires these neural circuits to ultimately prompt escape behaviors remains unclear. We observe that aversive stimuli, including foot-shocks, excite LHb neurons and promote escape behaviors in mice. The foot-shock-driven excitation within the LHb requires glutamatergic signaling from the LH, but not from the midbrain. This hypothalamic excitatory projection predominates over LHb neurons monosynaptically innervating aversion-encoding midbrain GABA cells. Finally, the selective chemogenetic silencing of the LH-to-LHb pathway impairs aversion-driven escape behaviors. These findings unveil a habenular neurocircuitry devoted to encode external threats and the consequent escape; a process that, if disrupted, may compromise the animal’s survival. |
format | Online Article Text |
id | pubmed-5606847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-56068472017-09-25 Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior Lecca, Salvatore Meye, Frank Julius Trusel, Massimo Tchenio, Anna Harris, Julia Schwarz, Martin Karl Burdakov, Denis Georges, Francois Mameli, Manuel eLife Neuroscience A sudden aversive event produces escape behaviors, an innate response essential for survival in virtually all-animal species. Nuclei including the lateral habenula (LHb), the lateral hypothalamus (LH), and the midbrain are not only reciprocally connected, but also respond to negative events contributing to goal-directed behaviors. However, whether aversion encoding requires these neural circuits to ultimately prompt escape behaviors remains unclear. We observe that aversive stimuli, including foot-shocks, excite LHb neurons and promote escape behaviors in mice. The foot-shock-driven excitation within the LHb requires glutamatergic signaling from the LH, but not from the midbrain. This hypothalamic excitatory projection predominates over LHb neurons monosynaptically innervating aversion-encoding midbrain GABA cells. Finally, the selective chemogenetic silencing of the LH-to-LHb pathway impairs aversion-driven escape behaviors. These findings unveil a habenular neurocircuitry devoted to encode external threats and the consequent escape; a process that, if disrupted, may compromise the animal’s survival. eLife Sciences Publications, Ltd 2017-09-05 /pmc/articles/PMC5606847/ /pubmed/28871962 http://dx.doi.org/10.7554/eLife.30697 Text en © 2017, Lecca et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Lecca, Salvatore Meye, Frank Julius Trusel, Massimo Tchenio, Anna Harris, Julia Schwarz, Martin Karl Burdakov, Denis Georges, Francois Mameli, Manuel Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior |
title | Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior |
title_full | Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior |
title_fullStr | Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior |
title_full_unstemmed | Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior |
title_short | Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior |
title_sort | aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606847/ https://www.ncbi.nlm.nih.gov/pubmed/28871962 http://dx.doi.org/10.7554/eLife.30697 |
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