Significant Improvement in Detecting BRAF, KRAS, and EGFR Mutations Using Next-Generation Sequencing as Compared with FDA-Cleared Kits

INTRODUCTION: We compared mutations detected in EGFR, KRAS, and BRAF genes using next-generation sequencing (NGS) and confirmed by Sanger sequencing with mutations that could be detected by FDA-cleared testing kits. METHODS: Paraffin-embedded tissue from 822 patients was tested for mutations in EGFR...

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Detalles Bibliográficos
Autores principales: Ma, Wanlong, Brodie, Steven, Agersborg, Sally, Funari, Vincent A., Albitar, Maher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606956/
https://www.ncbi.nlm.nih.gov/pubmed/28639239
http://dx.doi.org/10.1007/s40291-017-0290-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606956/
https://www.ncbi.nlm.nih.gov/pubmed/28639239
http://dx.doi.org/10.1007/s40291-017-0290-z

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