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ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death

Disruption of protein folding in the endoplasmic reticulum (ER) causes ER stress. Activation of the unfolded protein response (UPR) acts to restore protein homeostasis or, if ER stress is severe or persistent, drive apoptosis, which is thought to proceed through the cell intrinsic, mitochondrial pat...

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Detalles Bibliográficos
Autores principales:	Darling, Nicola J., Balmanno, Kathryn, Cook, Simon J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607168/ https://www.ncbi.nlm.nih.gov/pubmed/28931068 http://dx.doi.org/10.1371/journal.pone.0184907

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