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Methylation associated transcriptional repression of ELOVL5 in novel colorectal cancer cell lines

Genetic and epigenetic alterations mark colorectal cancer (CRC). Global hypomethylation is observed in nearly all CRC, but a distinct subset of CRC show the CpG Island Methylator Phenotype (CIMP). These tumors show DNA hypermethylation of a specific subset of CpG islands, resulting in transcriptiona...

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Detalles Bibliográficos
Autores principales:	Boot, Arnoud, Oosting, Jan, van Eendenburg, Jaap D. H., Kuppen, Peter J. K., Morreau, Hans, van Wezel, Tom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607170/ https://www.ncbi.nlm.nih.gov/pubmed/28931069 http://dx.doi.org/10.1371/journal.pone.0184900

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