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Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo
Ghrelin is a peptide hormone produced mainly in the gastrointestinal tract known to regulate several physiological functions including gut motility, adipose tissue accumulation and hunger sensation leading to increased bodyweight. Studies have found a correlation between the plasma levels of thyroid...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607171/ https://www.ncbi.nlm.nih.gov/pubmed/28931076 http://dx.doi.org/10.1371/journal.pone.0184992 |
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author | Barington, Maria Brorson, Marianne Møller Hofman-Bang, Jacob Rasmussen, Åse Krogh Holst, Birgitte Feldt-Rasmussen, Ulla |
author_facet | Barington, Maria Brorson, Marianne Møller Hofman-Bang, Jacob Rasmussen, Åse Krogh Holst, Birgitte Feldt-Rasmussen, Ulla |
author_sort | Barington, Maria |
collection | PubMed |
description | Ghrelin is a peptide hormone produced mainly in the gastrointestinal tract known to regulate several physiological functions including gut motility, adipose tissue accumulation and hunger sensation leading to increased bodyweight. Studies have found a correlation between the plasma levels of thyroid hormones and ghrelin, but an effect of ghrelin on the human thyroid has never been investigated even though ghrelin receptors are present in the thyroid. The present study shows a ghrelin-induced decrease in the thyroid-stimulating hormone (TSH)-induced production of thyroglobulin and mRNA expression of thyroperoxidase in a primary culture of human thyroid cells obtained from paranodular tissue. Accordingly, a trend was noted for an inhibition of TSH-stimulated expression of the sodium-iodine symporter and the TSH-receptor. Thus, this study suggests an effect of ghrelin on human thyrocytes and thereby emphasizes the relevance of examining whether ghrelin also influences the metabolic homeostasis through altered thyroid hormone production. |
format | Online Article Text |
id | pubmed-5607171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-56071712017-10-09 Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo Barington, Maria Brorson, Marianne Møller Hofman-Bang, Jacob Rasmussen, Åse Krogh Holst, Birgitte Feldt-Rasmussen, Ulla PLoS One Research Article Ghrelin is a peptide hormone produced mainly in the gastrointestinal tract known to regulate several physiological functions including gut motility, adipose tissue accumulation and hunger sensation leading to increased bodyweight. Studies have found a correlation between the plasma levels of thyroid hormones and ghrelin, but an effect of ghrelin on the human thyroid has never been investigated even though ghrelin receptors are present in the thyroid. The present study shows a ghrelin-induced decrease in the thyroid-stimulating hormone (TSH)-induced production of thyroglobulin and mRNA expression of thyroperoxidase in a primary culture of human thyroid cells obtained from paranodular tissue. Accordingly, a trend was noted for an inhibition of TSH-stimulated expression of the sodium-iodine symporter and the TSH-receptor. Thus, this study suggests an effect of ghrelin on human thyrocytes and thereby emphasizes the relevance of examining whether ghrelin also influences the metabolic homeostasis through altered thyroid hormone production. Public Library of Science 2017-09-20 /pmc/articles/PMC5607171/ /pubmed/28931076 http://dx.doi.org/10.1371/journal.pone.0184992 Text en © 2017 Barington et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Barington, Maria Brorson, Marianne Møller Hofman-Bang, Jacob Rasmussen, Åse Krogh Holst, Birgitte Feldt-Rasmussen, Ulla Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo |
title | Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo |
title_full | Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo |
title_fullStr | Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo |
title_full_unstemmed | Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo |
title_short | Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo |
title_sort | ghrelin-mediated inhibition of the tsh-stimulated function of differentiated human thyrocytes ex vivo |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607171/ https://www.ncbi.nlm.nih.gov/pubmed/28931076 http://dx.doi.org/10.1371/journal.pone.0184992 |
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