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Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo

Ghrelin is a peptide hormone produced mainly in the gastrointestinal tract known to regulate several physiological functions including gut motility, adipose tissue accumulation and hunger sensation leading to increased bodyweight. Studies have found a correlation between the plasma levels of thyroid...

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Autores principales: Barington, Maria, Brorson, Marianne Møller, Hofman-Bang, Jacob, Rasmussen, Åse Krogh, Holst, Birgitte, Feldt-Rasmussen, Ulla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607171/
https://www.ncbi.nlm.nih.gov/pubmed/28931076
http://dx.doi.org/10.1371/journal.pone.0184992
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author Barington, Maria
Brorson, Marianne Møller
Hofman-Bang, Jacob
Rasmussen, Åse Krogh
Holst, Birgitte
Feldt-Rasmussen, Ulla
author_facet Barington, Maria
Brorson, Marianne Møller
Hofman-Bang, Jacob
Rasmussen, Åse Krogh
Holst, Birgitte
Feldt-Rasmussen, Ulla
author_sort Barington, Maria
collection PubMed
description Ghrelin is a peptide hormone produced mainly in the gastrointestinal tract known to regulate several physiological functions including gut motility, adipose tissue accumulation and hunger sensation leading to increased bodyweight. Studies have found a correlation between the plasma levels of thyroid hormones and ghrelin, but an effect of ghrelin on the human thyroid has never been investigated even though ghrelin receptors are present in the thyroid. The present study shows a ghrelin-induced decrease in the thyroid-stimulating hormone (TSH)-induced production of thyroglobulin and mRNA expression of thyroperoxidase in a primary culture of human thyroid cells obtained from paranodular tissue. Accordingly, a trend was noted for an inhibition of TSH-stimulated expression of the sodium-iodine symporter and the TSH-receptor. Thus, this study suggests an effect of ghrelin on human thyrocytes and thereby emphasizes the relevance of examining whether ghrelin also influences the metabolic homeostasis through altered thyroid hormone production.
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spelling pubmed-56071712017-10-09 Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo Barington, Maria Brorson, Marianne Møller Hofman-Bang, Jacob Rasmussen, Åse Krogh Holst, Birgitte Feldt-Rasmussen, Ulla PLoS One Research Article Ghrelin is a peptide hormone produced mainly in the gastrointestinal tract known to regulate several physiological functions including gut motility, adipose tissue accumulation and hunger sensation leading to increased bodyweight. Studies have found a correlation between the plasma levels of thyroid hormones and ghrelin, but an effect of ghrelin on the human thyroid has never been investigated even though ghrelin receptors are present in the thyroid. The present study shows a ghrelin-induced decrease in the thyroid-stimulating hormone (TSH)-induced production of thyroglobulin and mRNA expression of thyroperoxidase in a primary culture of human thyroid cells obtained from paranodular tissue. Accordingly, a trend was noted for an inhibition of TSH-stimulated expression of the sodium-iodine symporter and the TSH-receptor. Thus, this study suggests an effect of ghrelin on human thyrocytes and thereby emphasizes the relevance of examining whether ghrelin also influences the metabolic homeostasis through altered thyroid hormone production. Public Library of Science 2017-09-20 /pmc/articles/PMC5607171/ /pubmed/28931076 http://dx.doi.org/10.1371/journal.pone.0184992 Text en © 2017 Barington et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Barington, Maria
Brorson, Marianne Møller
Hofman-Bang, Jacob
Rasmussen, Åse Krogh
Holst, Birgitte
Feldt-Rasmussen, Ulla
Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo
title Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo
title_full Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo
title_fullStr Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo
title_full_unstemmed Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo
title_short Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo
title_sort ghrelin-mediated inhibition of the tsh-stimulated function of differentiated human thyrocytes ex vivo
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607171/
https://www.ncbi.nlm.nih.gov/pubmed/28931076
http://dx.doi.org/10.1371/journal.pone.0184992
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