Cargando…

Factors associated with hepatitis C prevalence differ by the stage of liver fibrosis: A cross-sectional study in the general population in Poland, 2012-2016

BACKGROUND & AIMS: There is a considerable burden of hepatitis C in Europe related to the lack of prompt diagnosis. We aimed to estimate the prevalence and related risk factors of HCV infections by the stages of liver fibrosis, using non-invasive methods, to understand testing needs in Poland. M...

Descripción completa

Detalles Bibliográficos
Autores principales: Rosińska, Magdalena, Parda, Natalia, Kołakowska, Agnieszka, Godzik, Paulina, Zakrzewska, Karolina, Madaliński, Kazimierz, Zieliński, Andrzej, Boguradzka, Anna, Gierczyński, Rafał, Stępień, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607182/
https://www.ncbi.nlm.nih.gov/pubmed/28931062
http://dx.doi.org/10.1371/journal.pone.0185055
_version_ 1783265241810862080
author Rosińska, Magdalena
Parda, Natalia
Kołakowska, Agnieszka
Godzik, Paulina
Zakrzewska, Karolina
Madaliński, Kazimierz
Zieliński, Andrzej
Boguradzka, Anna
Gierczyński, Rafał
Stępień, Małgorzata
author_facet Rosińska, Magdalena
Parda, Natalia
Kołakowska, Agnieszka
Godzik, Paulina
Zakrzewska, Karolina
Madaliński, Kazimierz
Zieliński, Andrzej
Boguradzka, Anna
Gierczyński, Rafał
Stępień, Małgorzata
author_sort Rosińska, Magdalena
collection PubMed
description BACKGROUND & AIMS: There is a considerable burden of hepatitis C in Europe related to the lack of prompt diagnosis. We aimed to estimate the prevalence and related risk factors of HCV infections by the stages of liver fibrosis, using non-invasive methods, to understand testing needs in Poland. METHODS: A cross-sectional study was conducted in 2012–2016 adopting a stratified random sampling of primary health care units followed by systematic sampling of patients within each unit. Study participants filled a questionnaire and donated blood for laboratory HCV testing. Additionally, the results of liver function tests and platelet count were collected to calculate APRI and FIB-4 scores. Cases were classified according to the level of fibrosis: ‘significant fibrosis’ (APRI≥0.7 or FIB4≥1.45) and ‘no significant fibrosis’ (APRI<0.7 and FIB4<1.45). RESULTS: Of 21 875 study participants, 102 were HCV-RNA positive. Prevalence of HCV infections and significant fibrosis was estimated at 0.47% (95% CI 0.38% - 0.57%) and 0.12% (0.08% - 0.17%), respectively. Cases with significant fibrosis accounted for 51.6% (33.4%-69.9%) in men and 34.4% (17.3%-51.4%) in women. There was no correlation between the HCV prevalence and age. Blood transfusion prior to 1992 strongly predicted significant fibrosis as did the history of injecting drug use (IDU) and ever having an HCV-infected sexual partner in men and caesarean sections in women. Factors associated with HCV infection without significant fibrosis were tattooing in men and younger age in women. We acknowledge limited possibility to study the associations between IDU and ever having HCV-infected sexual partner, given small sample sizes for these exposures. CONCLUSIONS: As no clear birth cohort affected by HCV could be identified, risk factor-based screening in the general population should be considered, taking into account the association between the increased risk of liver fibrosis and the history of transfusion prior to 1992 and caesarean sections.
format Online
Article
Text
id pubmed-5607182
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-56071822017-10-09 Factors associated with hepatitis C prevalence differ by the stage of liver fibrosis: A cross-sectional study in the general population in Poland, 2012-2016 Rosińska, Magdalena Parda, Natalia Kołakowska, Agnieszka Godzik, Paulina Zakrzewska, Karolina Madaliński, Kazimierz Zieliński, Andrzej Boguradzka, Anna Gierczyński, Rafał Stępień, Małgorzata PLoS One Research Article BACKGROUND & AIMS: There is a considerable burden of hepatitis C in Europe related to the lack of prompt diagnosis. We aimed to estimate the prevalence and related risk factors of HCV infections by the stages of liver fibrosis, using non-invasive methods, to understand testing needs in Poland. METHODS: A cross-sectional study was conducted in 2012–2016 adopting a stratified random sampling of primary health care units followed by systematic sampling of patients within each unit. Study participants filled a questionnaire and donated blood for laboratory HCV testing. Additionally, the results of liver function tests and platelet count were collected to calculate APRI and FIB-4 scores. Cases were classified according to the level of fibrosis: ‘significant fibrosis’ (APRI≥0.7 or FIB4≥1.45) and ‘no significant fibrosis’ (APRI<0.7 and FIB4<1.45). RESULTS: Of 21 875 study participants, 102 were HCV-RNA positive. Prevalence of HCV infections and significant fibrosis was estimated at 0.47% (95% CI 0.38% - 0.57%) and 0.12% (0.08% - 0.17%), respectively. Cases with significant fibrosis accounted for 51.6% (33.4%-69.9%) in men and 34.4% (17.3%-51.4%) in women. There was no correlation between the HCV prevalence and age. Blood transfusion prior to 1992 strongly predicted significant fibrosis as did the history of injecting drug use (IDU) and ever having an HCV-infected sexual partner in men and caesarean sections in women. Factors associated with HCV infection without significant fibrosis were tattooing in men and younger age in women. We acknowledge limited possibility to study the associations between IDU and ever having HCV-infected sexual partner, given small sample sizes for these exposures. CONCLUSIONS: As no clear birth cohort affected by HCV could be identified, risk factor-based screening in the general population should be considered, taking into account the association between the increased risk of liver fibrosis and the history of transfusion prior to 1992 and caesarean sections. Public Library of Science 2017-09-20 /pmc/articles/PMC5607182/ /pubmed/28931062 http://dx.doi.org/10.1371/journal.pone.0185055 Text en © 2017 Rosińska et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Rosińska, Magdalena
Parda, Natalia
Kołakowska, Agnieszka
Godzik, Paulina
Zakrzewska, Karolina
Madaliński, Kazimierz
Zieliński, Andrzej
Boguradzka, Anna
Gierczyński, Rafał
Stępień, Małgorzata
Factors associated with hepatitis C prevalence differ by the stage of liver fibrosis: A cross-sectional study in the general population in Poland, 2012-2016
title Factors associated with hepatitis C prevalence differ by the stage of liver fibrosis: A cross-sectional study in the general population in Poland, 2012-2016
title_full Factors associated with hepatitis C prevalence differ by the stage of liver fibrosis: A cross-sectional study in the general population in Poland, 2012-2016
title_fullStr Factors associated with hepatitis C prevalence differ by the stage of liver fibrosis: A cross-sectional study in the general population in Poland, 2012-2016
title_full_unstemmed Factors associated with hepatitis C prevalence differ by the stage of liver fibrosis: A cross-sectional study in the general population in Poland, 2012-2016
title_short Factors associated with hepatitis C prevalence differ by the stage of liver fibrosis: A cross-sectional study in the general population in Poland, 2012-2016
title_sort factors associated with hepatitis c prevalence differ by the stage of liver fibrosis: a cross-sectional study in the general population in poland, 2012-2016
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607182/
https://www.ncbi.nlm.nih.gov/pubmed/28931062
http://dx.doi.org/10.1371/journal.pone.0185055
work_keys_str_mv AT rosinskamagdalena factorsassociatedwithhepatitiscprevalencedifferbythestageofliverfibrosisacrosssectionalstudyinthegeneralpopulationinpoland20122016
AT pardanatalia factorsassociatedwithhepatitiscprevalencedifferbythestageofliverfibrosisacrosssectionalstudyinthegeneralpopulationinpoland20122016
AT kołakowskaagnieszka factorsassociatedwithhepatitiscprevalencedifferbythestageofliverfibrosisacrosssectionalstudyinthegeneralpopulationinpoland20122016
AT godzikpaulina factorsassociatedwithhepatitiscprevalencedifferbythestageofliverfibrosisacrosssectionalstudyinthegeneralpopulationinpoland20122016
AT zakrzewskakarolina factorsassociatedwithhepatitiscprevalencedifferbythestageofliverfibrosisacrosssectionalstudyinthegeneralpopulationinpoland20122016
AT madalinskikazimierz factorsassociatedwithhepatitiscprevalencedifferbythestageofliverfibrosisacrosssectionalstudyinthegeneralpopulationinpoland20122016
AT zielinskiandrzej factorsassociatedwithhepatitiscprevalencedifferbythestageofliverfibrosisacrosssectionalstudyinthegeneralpopulationinpoland20122016
AT boguradzkaanna factorsassociatedwithhepatitiscprevalencedifferbythestageofliverfibrosisacrosssectionalstudyinthegeneralpopulationinpoland20122016
AT gierczynskirafał factorsassociatedwithhepatitiscprevalencedifferbythestageofliverfibrosisacrosssectionalstudyinthegeneralpopulationinpoland20122016
AT stepienmałgorzata factorsassociatedwithhepatitiscprevalencedifferbythestageofliverfibrosisacrosssectionalstudyinthegeneralpopulationinpoland20122016