Cargando…
Defective thymic output in WAS patients is associated with abnormal actin organization
Wiskott-Aldrich syndrome protein (WASp) is a key regulator of the actin cytoskeleton. Defective T - cell function is a major cause for immune deficiency in Wiskott-Aldrich syndrome (WAS) patients. T cells originate in the bone marrow and develop in the thymus, and then migrate to peripheral tissues....
Autores principales: | Li, Wenyan, Sun, Xiaoyu, Wang, Jinzhi, Zhao, Qin, Dai, Rongxin, Wang, Yanping, Zhou, Lina, Westerberg, Lisa, Ding, Yuan, Zhao, Xiaodong, Liu, Chaohong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607224/ https://www.ncbi.nlm.nih.gov/pubmed/28931895 http://dx.doi.org/10.1038/s41598-017-12345-z |
Ejemplares similares
-
Rictor positively regulates B cell receptor signaling by modulating actin reorganization via ezrin
por: Huang, Lu, et al.
Publicado: (2017) -
Decreased Thymic Output Contributes to Immune Defects in Septic Patients
por: Sommer, Natascha, et al.
Publicado: (2020) -
Congenital Defects in Actin Dynamics of Germinal Center B Cells
por: He, Minghui, et al.
Publicado: (2019) -
Bacillus Calmette-Guérin vaccination, thymic size, and thymic output in healthy newborns
por: Birk, Nina Marie, et al.
Publicado: (2017) -
Akt2 Regulates the Differentiation and Function of NKT17 Cells via FoxO-1-ICOS Axis
por: Niu, LinLin, et al.
Publicado: (2018)