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Antitumor effect of Ferula assa foetida oleo gum resin against breast cancer induced by 4T1 cells in BALB/c mice
BACKGROUND: Ferula assa foetida commonly consumed as a healthy beverage has been demonstrated to have various biological activities, including antioxidation, anti-obesity and anti-cancer. OBJECTIVE: Our study aims to investigate the antitumor effect of asafoetida in vivo using mouse mammary carcinom...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607392/ https://www.ncbi.nlm.nih.gov/pubmed/28690055 http://dx.doi.org/10.1016/j.jaim.2017.02.013 |
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author | Bagheri, Seyyed Majid Abdian-Asl, Amir Moghadam, Mahin Taheri Yadegari, Maryam Mirjalili, Aghdas Zare-Mohazabieh, Fatemeh Momeni, Haniyeh |
author_facet | Bagheri, Seyyed Majid Abdian-Asl, Amir Moghadam, Mahin Taheri Yadegari, Maryam Mirjalili, Aghdas Zare-Mohazabieh, Fatemeh Momeni, Haniyeh |
author_sort | Bagheri, Seyyed Majid |
collection | PubMed |
description | BACKGROUND: Ferula assa foetida commonly consumed as a healthy beverage has been demonstrated to have various biological activities, including antioxidation, anti-obesity and anti-cancer. OBJECTIVE: Our study aims to investigate the antitumor effect of asafoetida in vivo using mouse mammary carcinoma 4T1 cells. MATERIALS AND METHODS: In the study, female BALB/c mice were divided into two groups (n = 6), which were control (untreated) and other group of mice with breast cancer treated with 100 mg/kg of asafoetida, respectively, by oral gavage. All mice were injected into the mammary fat pad with 4T1 cells (1 × 10(5) 4T1 cells/0.1 ml of phosphate buffer solution). Asafoetida was administered on day 15 after the tumor had developed for 3 weeks. At end of experiment, tumor weight, tumor volume and tumor burden were measured and lung, liver, kidney and tumor were harvested and sections were prepared for histopathological analysis. Lipoxygenase inhibitory and antioxidant activity of asafoetida was also determined. RESULTS: Our results showed that treatment with asafoetida was effective in decreasing the tumor weight and tumor volume in treated mice. Body weight significantly increased in female BALB/c mice against control. Apart from the antitumor effect, asafoetida decreased lung, liver and kidney metastasis and also increased areas of necrosis in the tumor tissue respectively. CONCLUSIONS: The present study demonstrated that asafoetida has potent antitumor and antimetastasis effects on breast cancer and is a potential source of natural antitumor products. |
format | Online Article Text |
id | pubmed-5607392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-56073922017-09-26 Antitumor effect of Ferula assa foetida oleo gum resin against breast cancer induced by 4T1 cells in BALB/c mice Bagheri, Seyyed Majid Abdian-Asl, Amir Moghadam, Mahin Taheri Yadegari, Maryam Mirjalili, Aghdas Zare-Mohazabieh, Fatemeh Momeni, Haniyeh J Ayurveda Integr Med Original Research Article (Experimental) BACKGROUND: Ferula assa foetida commonly consumed as a healthy beverage has been demonstrated to have various biological activities, including antioxidation, anti-obesity and anti-cancer. OBJECTIVE: Our study aims to investigate the antitumor effect of asafoetida in vivo using mouse mammary carcinoma 4T1 cells. MATERIALS AND METHODS: In the study, female BALB/c mice were divided into two groups (n = 6), which were control (untreated) and other group of mice with breast cancer treated with 100 mg/kg of asafoetida, respectively, by oral gavage. All mice were injected into the mammary fat pad with 4T1 cells (1 × 10(5) 4T1 cells/0.1 ml of phosphate buffer solution). Asafoetida was administered on day 15 after the tumor had developed for 3 weeks. At end of experiment, tumor weight, tumor volume and tumor burden were measured and lung, liver, kidney and tumor were harvested and sections were prepared for histopathological analysis. Lipoxygenase inhibitory and antioxidant activity of asafoetida was also determined. RESULTS: Our results showed that treatment with asafoetida was effective in decreasing the tumor weight and tumor volume in treated mice. Body weight significantly increased in female BALB/c mice against control. Apart from the antitumor effect, asafoetida decreased lung, liver and kidney metastasis and also increased areas of necrosis in the tumor tissue respectively. CONCLUSIONS: The present study demonstrated that asafoetida has potent antitumor and antimetastasis effects on breast cancer and is a potential source of natural antitumor products. Elsevier 2017 2017-07-06 /pmc/articles/PMC5607392/ /pubmed/28690055 http://dx.doi.org/10.1016/j.jaim.2017.02.013 Text en © 2017 Transdisciplinary University, Bangalore and World Ayurveda Foundation. Publishing Services by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Article (Experimental) Bagheri, Seyyed Majid Abdian-Asl, Amir Moghadam, Mahin Taheri Yadegari, Maryam Mirjalili, Aghdas Zare-Mohazabieh, Fatemeh Momeni, Haniyeh Antitumor effect of Ferula assa foetida oleo gum resin against breast cancer induced by 4T1 cells in BALB/c mice |
title | Antitumor effect of Ferula assa foetida oleo gum resin against breast cancer induced by 4T1 cells in BALB/c mice |
title_full | Antitumor effect of Ferula assa foetida oleo gum resin against breast cancer induced by 4T1 cells in BALB/c mice |
title_fullStr | Antitumor effect of Ferula assa foetida oleo gum resin against breast cancer induced by 4T1 cells in BALB/c mice |
title_full_unstemmed | Antitumor effect of Ferula assa foetida oleo gum resin against breast cancer induced by 4T1 cells in BALB/c mice |
title_short | Antitumor effect of Ferula assa foetida oleo gum resin against breast cancer induced by 4T1 cells in BALB/c mice |
title_sort | antitumor effect of ferula assa foetida oleo gum resin against breast cancer induced by 4t1 cells in balb/c mice |
topic | Original Research Article (Experimental) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607392/ https://www.ncbi.nlm.nih.gov/pubmed/28690055 http://dx.doi.org/10.1016/j.jaim.2017.02.013 |
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