Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases

[Image: see text] Secreted virulence factors like bacterial collagenases are conceptually attractive targets for fighting microbial infections. However, previous attempts to develop potent compounds against these metalloproteases failed to achieve selectivity against human matrix metalloproteinases...

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Detalles Bibliográficos
Autores principales: Schönauer, Esther, Kany, Andreas M., Haupenthal, Jörg, Hüsecken, Kristina, Hoppe, Isabel J., Voos, Katrin, Yahiaoui, Samir, Elsässer, Brigitta, Ducho, Christian, Brandstetter, Hans, Hartmann, Rolf W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607459/
https://www.ncbi.nlm.nih.gov/pubmed/28820255
http://dx.doi.org/10.1021/jacs.7b06935

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