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Detection and application of neurochemical profile by multiple regional (1)H‐MRS in Parkinson's disease

INTRODUCTION: The accurate diagnosis and monitoring of idiopathic Parkinson disease (PD), a progressive neurodegenerative disorder, has not been fully developed. This study sought to identify a neurochemical profile in multiple regions of the PD brain and healthy controls by proton magnetic resonanc...

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Autores principales: Guan, Jitian, Rong, Yu, Wen, Ye, Wu, Huanze, Qin, Hong, Zhang, Qingying, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607555/
https://www.ncbi.nlm.nih.gov/pubmed/28948086
http://dx.doi.org/10.1002/brb3.792
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author Guan, Jitian
Rong, Yu
Wen, Ye
Wu, Huanze
Qin, Hong
Zhang, Qingying
Chen, Wei
author_facet Guan, Jitian
Rong, Yu
Wen, Ye
Wu, Huanze
Qin, Hong
Zhang, Qingying
Chen, Wei
author_sort Guan, Jitian
collection PubMed
description INTRODUCTION: The accurate diagnosis and monitoring of idiopathic Parkinson disease (PD), a progressive neurodegenerative disorder, has not been fully developed. This study sought to identify a neurochemical profile in multiple regions of the PD brain and healthy controls by proton magnetic resonance spectroscopy ((1)H‐MRS). We aimed to track changes of the brain neurochemical, quantify neuronal loss, and further determine the diagnostic value of (1)H‐MRS. METHODS: PD patients and healthy controls recruited from Second Affiliated Hospital of Shantou University Medical College, Shantou, southern China, underwent (1)H‐MRS. Chemical information was obtained for ratios of N‐acetylaspartate to creatine (NAA/Cr), NAA to choline (NAA/Cho), and Cho to Cr for substantia nigra, globus pallidus, prefrontal lobe, hippocampus, cuneus gyrus, and dorsal thalamus regions. RESULTS: Compared to the 20 healthy controls (12 male, age 58.75 ± 5.03 years), the 42 patients (21 male, age 61.60 ± 6.40 years) showed lower NAA/Cr and NAA/Cho ratios in substantia nigra, globus pallidus, prefrontal lobe, hippocampus, cuneus gyrus and dorsal thalamus regions (p < .01); NAA/Cr and NAA/Cho ratios were reduced for both patients with unilateral and mild/no cognitive impairment (p < .01); Unified Parkinson's Disease Rating Scale score was inversely correlated with NAA/Cr ratios in the substantia nigra (r = −.32; p = .042). CONCLUSION: NAA/Cr and NAA/Cho ratios may be useful metabolic biomarkers for early diagnosis of PD. Multi‐voxel (1)H‐MRS can provide information on brain neurochemistry and may be a promising technique for diagnosis of and monitoring neuronal loss in PD.
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spelling pubmed-56075552017-09-25 Detection and application of neurochemical profile by multiple regional (1)H‐MRS in Parkinson's disease Guan, Jitian Rong, Yu Wen, Ye Wu, Huanze Qin, Hong Zhang, Qingying Chen, Wei Brain Behav Original Research INTRODUCTION: The accurate diagnosis and monitoring of idiopathic Parkinson disease (PD), a progressive neurodegenerative disorder, has not been fully developed. This study sought to identify a neurochemical profile in multiple regions of the PD brain and healthy controls by proton magnetic resonance spectroscopy ((1)H‐MRS). We aimed to track changes of the brain neurochemical, quantify neuronal loss, and further determine the diagnostic value of (1)H‐MRS. METHODS: PD patients and healthy controls recruited from Second Affiliated Hospital of Shantou University Medical College, Shantou, southern China, underwent (1)H‐MRS. Chemical information was obtained for ratios of N‐acetylaspartate to creatine (NAA/Cr), NAA to choline (NAA/Cho), and Cho to Cr for substantia nigra, globus pallidus, prefrontal lobe, hippocampus, cuneus gyrus, and dorsal thalamus regions. RESULTS: Compared to the 20 healthy controls (12 male, age 58.75 ± 5.03 years), the 42 patients (21 male, age 61.60 ± 6.40 years) showed lower NAA/Cr and NAA/Cho ratios in substantia nigra, globus pallidus, prefrontal lobe, hippocampus, cuneus gyrus and dorsal thalamus regions (p < .01); NAA/Cr and NAA/Cho ratios were reduced for both patients with unilateral and mild/no cognitive impairment (p < .01); Unified Parkinson's Disease Rating Scale score was inversely correlated with NAA/Cr ratios in the substantia nigra (r = −.32; p = .042). CONCLUSION: NAA/Cr and NAA/Cho ratios may be useful metabolic biomarkers for early diagnosis of PD. Multi‐voxel (1)H‐MRS can provide information on brain neurochemistry and may be a promising technique for diagnosis of and monitoring neuronal loss in PD. John Wiley and Sons Inc. 2017-08-13 /pmc/articles/PMC5607555/ /pubmed/28948086 http://dx.doi.org/10.1002/brb3.792 Text en © 2017 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Guan, Jitian
Rong, Yu
Wen, Ye
Wu, Huanze
Qin, Hong
Zhang, Qingying
Chen, Wei
Detection and application of neurochemical profile by multiple regional (1)H‐MRS in Parkinson's disease
title Detection and application of neurochemical profile by multiple regional (1)H‐MRS in Parkinson's disease
title_full Detection and application of neurochemical profile by multiple regional (1)H‐MRS in Parkinson's disease
title_fullStr Detection and application of neurochemical profile by multiple regional (1)H‐MRS in Parkinson's disease
title_full_unstemmed Detection and application of neurochemical profile by multiple regional (1)H‐MRS in Parkinson's disease
title_short Detection and application of neurochemical profile by multiple regional (1)H‐MRS in Parkinson's disease
title_sort detection and application of neurochemical profile by multiple regional (1)h‐mrs in parkinson's disease
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607555/
https://www.ncbi.nlm.nih.gov/pubmed/28948086
http://dx.doi.org/10.1002/brb3.792
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