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IL-4-induced caveolin-1-containing lipid rafts aggregation contributes to MUC5AC synthesis in bronchial epithelial cells

BACKGROUND: Mucus overproduction is an important feature of asthma. Interleukin (IL)-4 is required for allergen-induced airway inflammation and mucus production. MUC5AC gene expression is regulated by transcript factors NF-κB. The intracellular Ca(2+) ([Ca(2+)](i)) signal is required for activation...

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Detalles Bibliográficos
Autores principales:	Xia, Yu, Cai, Peng-Cheng, Yu, Fan, Xiong, Liang, He, Xin-Liang, Rao, Shan-Shan, Chen, Feng, Yang, Xiang-Ping, Ma, Wan-Li, Ye, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607571/ https://www.ncbi.nlm.nih.gov/pubmed/28931396 http://dx.doi.org/10.1186/s12931-017-0657-z

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