The Global Lung Function Initiative (GLI) Network: bringing the world’s respiratory reference values together

The Global Lung Function Initiative (GLI) Network has become the largest resource for reference values for routine lung function testing ever assembled. This article addresses how the GLI Network came about, why it is important, and its current challenges and future directions. It is an extension of an article published in Breathe in 2013 [1], and summarises recent developments and the future of the GLI Network. KEY POINTS: The Global Lung Function Initiative (GLI) Network was established as a result of international collaboration, and altruism between researchers, clinicians and industry partners. The ongoing success of the GLI relies on network members continuing to work together to further improve how lung function is reported and interpreted across all age groups around the world. The GLI Network has produced standardised lung function reference values for spirometry and gas transfer tests. GLI reference equations should be adopted immediately for spirometry and gas transfer by clinicians and physiologists worldwide. The recently established GLI data repository will allow ongoing development and evaluation of reference values, and will offer opportunities for novel research. EDUCATIONAL AIMS: To highlight the advances made by the GLI Network during the past 5 years. To highlight the importance of using GLI reference values for routine lung function testing (e.g. spirometry and gas transfer tests). To discuss the challenges that remain for developing and improving reference values for lung function tests.