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Lentivirus-mediated interleukin-1β (IL-1β) knock-down in the hippocampus alleviates lipopolysaccharide (LPS)-induced memory deficits and anxiety- and depression-like behaviors in mice

BACKGROUND: Recent evidence has suggested that peripheral inflammatory responses induced by lipopolysaccharides (LPS) play an important role in neuropsychiatric dysfunction in rodents. Interleukin-1β (IL-1β), a pro-inflammatory cytokine, has been proposed to be a key mediator in a variety of behavio...

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Detalles Bibliográficos
Autores principales:	Li, Mengmeng, Li, Chenli, Yu, Hanjie, Cai, Xiongxiong, Shen, Xinbei, Sun, Xin, Wang, Jinting, Zhang, Yanhua, Wang, Chuang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607621/ https://www.ncbi.nlm.nih.gov/pubmed/28931410 http://dx.doi.org/10.1186/s12974-017-0964-9

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