Cargando…

Inhibition of Hes1 enhances lapatinib sensitivity in gastric cancer sphere-forming cells

It has been considered that the neurogenic locus notch homolog protein (Notch) signaling pathway serves an essential role in cellular differentiation, proliferation and apoptosis. However, the function of the Notch signaling pathway in gastric cancer stem cells (GCSCs) and epidermal growth factor re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Luchun, Li, Yan, Wang, Lulu, Wu, Zhijuan, Ma, Huiwen, Shao, Jianghe, Li, Dairong, Yu, Huiqing, Nian, Weiqi, Wang, Donglin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607651/ https://www.ncbi.nlm.nih.gov/pubmed/28959362 http://dx.doi.org/10.3892/ol.2017.6683

Ejemplares similares

Role of Kruppel-like factor 4 in regulating inhibitor of apoptosis-stimulating protein of p53 in the progression of gastric cancer
por: Wang, Lulu, et al.
Publicado: (2018)

The effect of icotinib combined with chemotherapy in untreated non-small-cell lung cancer that harbored EGFR-sensitive mutations in a real-life setting: a retrospective analysis
por: Wang, Lulu, et al.
Publicado: (2018)

miR-223 functions as a potent tumor suppressor of the Lewis lung carcinoma cell line by targeting insulin-like growth factor-1 receptor and cyclin-dependent kinase 2
por: NIAN, WEIQI, et al.
Publicado: (2013)

Therapeutic Mechanism of Lapatinib Combined with Sulforaphane on Gastric Cancer
por: Yi, Huixing, et al.
Publicado: (2021)

Hyperhomocysteinemia induces injury in olfactory bulb neurons by downregulating Hes1 and Hes5 expression
por: Zhang, Jing-wen, et al.
Publicado: (2018)

Identification of lapatinib sensitivity-related genes by integrative functional module analysis
por: Yuan, Qi-Hua, et al.
Publicado: (2020)

He’s Come!!
por: Stewart, A. T.
Publicado: (1869)

Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development
por: Li, Shuangding, et al.
Publicado: (2008)

Differential Sensitivity of ERBB2 Kinase Domain Mutations towards Lapatinib
por: Kancha, Rama Krishna, et al.
Publicado: (2011)

Sumoylation of Hes6 Regulates Protein Degradation and Hes1-Mediated Transcription
por: Lee, Jiwon, et al.
Publicado: (2015)

Circular RNA MYLK Promotes Glycolysis and Proliferation of Non-Small Cell Lung Cancer Cells by Sponging miR-195-5p and Increasing Glucose Transporter Member 3 Expression
por: Xiong, Shuanglong, et al.
Publicado: (2020)

Molecular effects of Lapatinib in the treatment of HER2 overexpressing oesophago-gastric adenocarcinoma
por: De Silva, Nadeera, et al.
Publicado: (2015)

Lapatinib promotes the incidence of hepatotoxicity by increasing chemotherapeutic agent accumulation in hepatocytes
por: Dai, ChunLing, et al.
Publicado: (2015)

Changes in the degree of substitution of HES in vivo and their influence on methods for determining HES concentrations in plasma
por: Lukasewitz, Peter, et al.
Publicado: (2023)

A randomized phase II study of lapatinib + pazopanib versus lapatinib in patients with HER2+ inflammatory breast cancer
por: Cristofanilli, Massimo, et al.
Publicado: (2012)

LncRNAs GIHCG and SPINT1-AS1 Are Crucial Factors for Pan-Cancer Cells Sensitivity to Lapatinib
por: Xiang, Zhen, et al.
Publicado: (2019)

Th1 cytokines sensitize HER-expressing breast cancer cells to lapatinib
por: Showalter, Loral E., et al.
Publicado: (2019)

Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer
por: Leung, Wing-yin, et al.
Publicado: (2015)

Self-Assembly in ultrahigh molecular weight sphere-forming diblock copolymer thin films under strong confinement
por: Cao, Wei, et al.
Publicado: (2019)

‘When he’s up there he’s just happy and content’: Parents’ perceptions of therapeutic horseback riding
por: Boyd, Lauren, et al.
Publicado: (2017)

Real‐world data of lapatinib and treatment after lapatinib in patients with previously treated HER2‐positive metastatic breast cancer: A multicenter, retrospective study
por: Xie, Yizhao, et al.
Publicado: (2020)

Identification of the xenograft and its ascendant sphere-forming cell line as belonging to EBV-induced lymphoma, and characterization of the status of sphere-forming cells
por: Dolgova, Evgeniya V., et al.
Publicado: (2019)

Characteristics and Predictors of Venous Thromboembolism Among Lymphoma Patients Undergoing Chemotherapy: A Cohort Study in China
por: Chen, Yue, et al.
Publicado: (2022)

HBx sensitizes hepatocellular carcinoma cells to lapatinib by up-regulating ErbB3
por: Chen, Jhen-Yu, et al.
Publicado: (2015)

Lapatinib sensitivity in nasopharyngeal carcinoma is modulated by SIRT2-mediated FOXO3 deacetylation
por: Aimjongjun, Sathid, et al.
Publicado: (2019)

HES6-1 and HES6-2 Function through Different Mechanisms during Neuronal Differentiation
por: Vilas-Boas, Filipe, et al.
Publicado: (2010)

Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs
por: Kuretani, Aya, et al.
Publicado: (2021)

Lapatinib for the treatment of breast cancer in the People’s Republic of China
por: Wang, Hongjiang
Publicado: (2014)

Lapatinib and lapatinib plus trastuzumab therapy versus trastuzumab therapy for HER2 positive breast cancer patients: an updated systematic review and meta-analysis
por: Yuan, Ye, et al.
Publicado: (2022)

HES-Mediated Repression of Pten in Caenorhabditis elegans
por: Chou, Han Ting, et al.
Publicado: (2015)

Conformal symmetry breaking operators for differential forms on spheres
por: Kobayashi, Toshiyuki, et al.
Publicado: (2016)

Antibiotics inhibit sphere-forming ability in suspension culture
por: Relier, Sébastien, et al.
Publicado: (2016)

Hes1 deficiency causes hematopoietic stem cell exhaustion
por: Ma, Zhilin, et al.
Publicado: (2020)

CD49f(high) Cells Retain Sphere-Forming and Tumor-Initiating Activities in Human Gastric Tumors
por: Fukamachi, Hiroshi, et al.
Publicado: (2013)

Hes1 regulates anagen initiation and hair follicle regeneration through modulation of hedgehog signaling
por: Suen, Wei‐Jeng, et al.
Publicado: (2019)

HES 130/0.4, a new HES specification: tissue storage after multiple infusions in rats
por: Bepperling, F, et al.
Publicado: (1999)

Hes-6, an inhibitor of Hes-1, is regulated by 17β-estradiol and promotes breast cancer cell proliferation
por: Hartman, Johan, et al.
Publicado: (2009)

NOTCH4(ΔL12_16) sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1
por: Zhang, Bin, et al.
Publicado: (2023)

The Complex Toxicity of Tetracycline with Polystyrene Spheres on Gastric Cancer Cells
por: Yan, Xiemin, et al.
Publicado: (2020)

Immunomodulatory and Antitumor Effects of a Novel TLR7 Agonist Combined with Lapatinib
por: Gao, Ningning, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_pt4bdbr9m7q37o3s1l4mnt9eiu