GuideScan software for improved single and paired CRISPR guide RNA design

We present GuideScan software for the design of CRISPR guide RNA libraries that can be used to edit coding and noncoding genomic regions. GuideScan produces high-density sets of gRNAs for single- and paired-gRNA genome-wide screens. We also show that by using a trie data structure GuideScan designs...

Descripción completa

Detalles Bibliográficos
Autores principales: Perez, Alexendar R., Pritykin, Yuri, Vidigal, Joana A., Chhangawala, Sagar, Zamparo, Lee, Leslie, Christina S., Ventura, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607865/
https://www.ncbi.nlm.nih.gov/pubmed/28263296
http://dx.doi.org/10.1038/nbt.3804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607865/
https://www.ncbi.nlm.nih.gov/pubmed/28263296
http://dx.doi.org/10.1038/nbt.3804

Ejemplares similares