Engineering microbial physiology with synthetic polymers: cationic polymers induce biofilm formation in Vibrio cholerae and downregulate the expression of virulence genes

Here we report the first application of non-bactericidal synthetic polymers to modulate the physiology of a bacterial pathogen. Poly(N-[3-(dimethylamino)propyl] methacrylamide) (P1) and poly(N-(3-aminopropyl)methacrylamide) (P2), cationic polymers that bind to the surface of V. cholerae, the infecti...

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Detalles Bibliográficos
Autores principales: Perez-Soto, Nicolas, Moule, Lauren, Crisan, Daniel N., Insua, Ignacio, Taylor-Smith, Leanne M., Voelz, Kerstin, Fernandez-Trillo, Francisco, Krachler, Anne Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607900/
https://www.ncbi.nlm.nih.gov/pubmed/28970909
http://dx.doi.org/10.1039/c7sc00615b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607900/
https://www.ncbi.nlm.nih.gov/pubmed/28970909
http://dx.doi.org/10.1039/c7sc00615b

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