Cargando…
Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review
CONTEXT: Kidney is one of the vital organs maintaining homeostasis of body and thus dysfunction of kidney affects quality of life and health severely. Anticancer drugs, particularly chemotherapeutic agents, cause high toxicity leading kidney dysfunction and irreparable kidney injury. Therefore, atte...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society of Diabetic Nephropathy Prevention
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607991/ https://www.ncbi.nlm.nih.gov/pubmed/28975109 http://dx.doi.org/10.15171/jnp.2017.41 |
_version_ | 1783265370999619584 |
---|---|
author | Heidari-Soreshjani, Saeid Asadi-Samani, Majid Yang, Qian Saeedi-Boroujeni, Ali |
author_facet | Heidari-Soreshjani, Saeid Asadi-Samani, Majid Yang, Qian Saeedi-Boroujeni, Ali |
author_sort | Heidari-Soreshjani, Saeid |
collection | PubMed |
description | CONTEXT: Kidney is one of the vital organs maintaining homeostasis of body and thus dysfunction of kidney affects quality of life and health severely. Anticancer drugs, particularly chemotherapeutic agents, cause high toxicity leading kidney dysfunction and irreparable kidney injury. Therefore, attention has recently been paid to seeking out alternatives such as nature-based drugs that are effective but less toxic. In this regard, this systematic review article is to report and introduce the most important medicinal plants and their derivatives that are used to reduce anticancer drug-induced nephrotoxicity. Evidence Acquisitions: The word nephrotoxicity alongside the words cancer or chemotherapy in combination with some herbal terms such as medicinal plant, plants, herbs, and extracts were administered to search for relevant publications indexed in PubMed. RESULTS: According to this study, 16 medicinal plants, 12 plant-based derivatives, and three traditional plant-based formulations were found to help control and modulate anticancer drug-induced nephrotoxicity indices. CONCLUSIONS: Anticancer drugs cause nephrotoxicity through activating pathways of oxidative stress, damage-associated molecular patterns (DAMPs) production, inflammatory processes, and cell apoptosis, while medicinal plants and their derivatives can cause reduction in nephrotoxicity and anticancer drugs side effects via their antioxidant and anti-inflammatory properties. |
format | Online Article Text |
id | pubmed-5607991 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Society of Diabetic Nephropathy Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-56079912017-10-03 Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review Heidari-Soreshjani, Saeid Asadi-Samani, Majid Yang, Qian Saeedi-Boroujeni, Ali J Nephropathol Review CONTEXT: Kidney is one of the vital organs maintaining homeostasis of body and thus dysfunction of kidney affects quality of life and health severely. Anticancer drugs, particularly chemotherapeutic agents, cause high toxicity leading kidney dysfunction and irreparable kidney injury. Therefore, attention has recently been paid to seeking out alternatives such as nature-based drugs that are effective but less toxic. In this regard, this systematic review article is to report and introduce the most important medicinal plants and their derivatives that are used to reduce anticancer drug-induced nephrotoxicity. Evidence Acquisitions: The word nephrotoxicity alongside the words cancer or chemotherapy in combination with some herbal terms such as medicinal plant, plants, herbs, and extracts were administered to search for relevant publications indexed in PubMed. RESULTS: According to this study, 16 medicinal plants, 12 plant-based derivatives, and three traditional plant-based formulations were found to help control and modulate anticancer drug-induced nephrotoxicity indices. CONCLUSIONS: Anticancer drugs cause nephrotoxicity through activating pathways of oxidative stress, damage-associated molecular patterns (DAMPs) production, inflammatory processes, and cell apoptosis, while medicinal plants and their derivatives can cause reduction in nephrotoxicity and anticancer drugs side effects via their antioxidant and anti-inflammatory properties. Society of Diabetic Nephropathy Prevention 2017-07 2017-02-16 /pmc/articles/PMC5607991/ /pubmed/28975109 http://dx.doi.org/10.15171/jnp.2017.41 Text en © 2017 The Author(s) Published by Society of Diabetic Nephropathy Prevention. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Heidari-Soreshjani, Saeid Asadi-Samani, Majid Yang, Qian Saeedi-Boroujeni, Ali Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review |
title | Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review |
title_full | Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review |
title_fullStr | Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review |
title_full_unstemmed | Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review |
title_short | Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review |
title_sort | phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607991/ https://www.ncbi.nlm.nih.gov/pubmed/28975109 http://dx.doi.org/10.15171/jnp.2017.41 |
work_keys_str_mv | AT heidarisoreshjanisaeid phytotherapyofnephrotoxicityinducedbycancerdrugsanupdatedreview AT asadisamanimajid phytotherapyofnephrotoxicityinducedbycancerdrugsanupdatedreview AT yangqian phytotherapyofnephrotoxicityinducedbycancerdrugsanupdatedreview AT saeediboroujeniali phytotherapyofnephrotoxicityinducedbycancerdrugsanupdatedreview |