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Voxel-based Histographic Analysis of the Basilar Artery in Patients with Isolated Pontine Infarction

BACKGROUND AND PURPOSE: The signal information per voxels of magnetic resonance imaging (MRI) for vessel wall could reflect the pathologic features of atherosclerotic vessels. The aim of this study is to evaluate the usefulness of magnetic resonance voxel-based histogram (VBH) of atherosclerotic bas...

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Autores principales: JANG, Han Won, LEE, Hui Joong, LEE, Jongmin, WON, Chulho, YOUN, Sung Won, HAN, Mun, CHANG, Yongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Magnetic Resonance in Medicine 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608109/
https://www.ncbi.nlm.nih.gov/pubmed/26902678
http://dx.doi.org/10.2463/mrms.mp.2015-0103
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author JANG, Han Won
LEE, Hui Joong
LEE, Jongmin
WON, Chulho
YOUN, Sung Won
HAN, Mun
CHANG, Yongmin
author_facet JANG, Han Won
LEE, Hui Joong
LEE, Jongmin
WON, Chulho
YOUN, Sung Won
HAN, Mun
CHANG, Yongmin
author_sort JANG, Han Won
collection PubMed
description BACKGROUND AND PURPOSE: The signal information per voxels of magnetic resonance imaging (MRI) for vessel wall could reflect the pathologic features of atherosclerotic vessels. The aim of this study is to evaluate the usefulness of magnetic resonance voxel-based histogram (VBH) of atherosclerotic basilar artery in patients with isolated pontine infarctions (PIs). MATERIALS AND METHODS: Wall and lumen of basilar artery were segmented from high resolution MR of 42 patients with isolated PI and 10 normal volunteers. VBHs were obtained after normalization by dividing the intensity of segmented wall with the intensity of non-infarcted area of pons. The variables of VBH included area (A), mean signal intensity (SI), standard deviation (SD), kurtosis (K), and skewness (SK) and area stenosis [AS; A(wall)/(A(wall) + A(lumen))] were compared according to the MRI-modified American Heart Association (AHA) atherosclerotic plaque schema, and between the subgroups of PI (lacunar: LPI and paramedian: PPI). RESULTS: According to the MRI-modified AHA atherosclerotic plaque schema, A(wall/T(1)) (mean area of wall on T(1)-weighted MRI), SI(wall/T(1)), SD(wall/T(1)), SK(wall/T(1)), K(wall/T(1)), A(lumen/T(1)), and AS(T(1)) showed statistical differences. AHA IV–VII showed higher A(wall/T(1)), SI(wall/T(1)), and AS(T(1)) than normal control. PPI showed statistical differences in A(wall/T(1)), SI(wall/T(1)), SK (wall/T(1)), and A(wall/T(2)) than those of normal control after post hoc test, whereas LPI in A(wall/T(1)) and A(wall/T(2)) (P < 0.05, Kruskal-Wallis test, Dunnett T3 procedure). CONCLUSIONS: VBH analysis can provide the quantitative information with regard to volume as well as composition of the atherosclerotic plaque in the basilar artery. The difference in patterns of VBH might be further useful in characterizing PIs with presumably different pathogenesis.
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spelling pubmed-56081092017-10-23 Voxel-based Histographic Analysis of the Basilar Artery in Patients with Isolated Pontine Infarction JANG, Han Won LEE, Hui Joong LEE, Jongmin WON, Chulho YOUN, Sung Won HAN, Mun CHANG, Yongmin Magn Reson Med Sci Major Paper BACKGROUND AND PURPOSE: The signal information per voxels of magnetic resonance imaging (MRI) for vessel wall could reflect the pathologic features of atherosclerotic vessels. The aim of this study is to evaluate the usefulness of magnetic resonance voxel-based histogram (VBH) of atherosclerotic basilar artery in patients with isolated pontine infarctions (PIs). MATERIALS AND METHODS: Wall and lumen of basilar artery were segmented from high resolution MR of 42 patients with isolated PI and 10 normal volunteers. VBHs were obtained after normalization by dividing the intensity of segmented wall with the intensity of non-infarcted area of pons. The variables of VBH included area (A), mean signal intensity (SI), standard deviation (SD), kurtosis (K), and skewness (SK) and area stenosis [AS; A(wall)/(A(wall) + A(lumen))] were compared according to the MRI-modified American Heart Association (AHA) atherosclerotic plaque schema, and between the subgroups of PI (lacunar: LPI and paramedian: PPI). RESULTS: According to the MRI-modified AHA atherosclerotic plaque schema, A(wall/T(1)) (mean area of wall on T(1)-weighted MRI), SI(wall/T(1)), SD(wall/T(1)), SK(wall/T(1)), K(wall/T(1)), A(lumen/T(1)), and AS(T(1)) showed statistical differences. AHA IV–VII showed higher A(wall/T(1)), SI(wall/T(1)), and AS(T(1)) than normal control. PPI showed statistical differences in A(wall/T(1)), SI(wall/T(1)), SK (wall/T(1)), and A(wall/T(2)) than those of normal control after post hoc test, whereas LPI in A(wall/T(1)) and A(wall/T(2)) (P < 0.05, Kruskal-Wallis test, Dunnett T3 procedure). CONCLUSIONS: VBH analysis can provide the quantitative information with regard to volume as well as composition of the atherosclerotic plaque in the basilar artery. The difference in patterns of VBH might be further useful in characterizing PIs with presumably different pathogenesis. Japanese Society for Magnetic Resonance in Medicine 2016-02-20 /pmc/articles/PMC5608109/ /pubmed/26902678 http://dx.doi.org/10.2463/mrms.mp.2015-0103 Text en © 2016 Japanese Society for Magnetic Resonance in Medicine http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives International License.
spellingShingle Major Paper
JANG, Han Won
LEE, Hui Joong
LEE, Jongmin
WON, Chulho
YOUN, Sung Won
HAN, Mun
CHANG, Yongmin
Voxel-based Histographic Analysis of the Basilar Artery in Patients with Isolated Pontine Infarction
title Voxel-based Histographic Analysis of the Basilar Artery in Patients with Isolated Pontine Infarction
title_full Voxel-based Histographic Analysis of the Basilar Artery in Patients with Isolated Pontine Infarction
title_fullStr Voxel-based Histographic Analysis of the Basilar Artery in Patients with Isolated Pontine Infarction
title_full_unstemmed Voxel-based Histographic Analysis of the Basilar Artery in Patients with Isolated Pontine Infarction
title_short Voxel-based Histographic Analysis of the Basilar Artery in Patients with Isolated Pontine Infarction
title_sort voxel-based histographic analysis of the basilar artery in patients with isolated pontine infarction
topic Major Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608109/
https://www.ncbi.nlm.nih.gov/pubmed/26902678
http://dx.doi.org/10.2463/mrms.mp.2015-0103
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