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Validation of autism spectrum disorder diagnoses recorded in the Clinical Practice Research Datalink, 1990–2014
BACKGROUND: Prior studies have reported that the validity of autism spectrum disorder (ASD) diagnoses recorded in the Clinical Practice Research Datalink (CPRD) was high; however, diagnostic criteria and screening practices have changed since the last study was published in 2004. OBJECTIVES: 1) To c...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608225/ https://www.ncbi.nlm.nih.gov/pubmed/28979165 http://dx.doi.org/10.2147/CLEP.S139107 |
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author | Hagberg, Katrina Wilcox Jick, Susan S |
author_facet | Hagberg, Katrina Wilcox Jick, Susan S |
author_sort | Hagberg, Katrina Wilcox |
collection | PubMed |
description | BACKGROUND: Prior studies have reported that the validity of autism spectrum disorder (ASD) diagnoses recorded in the Clinical Practice Research Datalink (CPRD) was high; however, diagnostic criteria and screening practices have changed since the last study was published in 2004. OBJECTIVES: 1) To calculate the positive predictive value (PPV) of ASD diagnoses recorded in the CPRD compared to original medical records and 2) to describe characteristics of cases and use of clinical codes that support the ASD diagnosis as recorded in the electronic data by general practitioners over time. METHODS: We identified children with a code for ASD (autism spectrum disorder, autism, Asperger’s, or pervasive developmental disorder) in the CPRD from 1990 to 2014. We evaluated presence of codes in the electronic medical record indicating the presence of developmental delay, speech delay, behavioral problems, and other supporting clinical codes (e.g., therapy, referrals, etc.). We also evaluated changes in recording of these clinical codes over time. We compared the information present in the electronic medical record to original medical records for a sample of cases and calculated PPVs of ASD diagnoses recorded in the CPRD. RESULTS: We identified 2154 children with a code for ASD. The mean age at diagnosis was 5.8 years, and 84% of cases were male. The majority (78.4%) had 1 ASD diagnosis code in their electronic medical record. Approximately half of the cases had a code indicating behavioral problem, developmental delay, or speech delay, and 24.7% had a code indicating specialist referral or visit. After review of original medical records, the PPV of ASD diagnoses recorded in the CPRD was 91.9%. CONCLUSION: The results of this study suggest that ASD diagnoses recorded in the CPRD are reliable and can be used with confidence to study ASD. |
format | Online Article Text |
id | pubmed-5608225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-56082252017-10-04 Validation of autism spectrum disorder diagnoses recorded in the Clinical Practice Research Datalink, 1990–2014 Hagberg, Katrina Wilcox Jick, Susan S Clin Epidemiol Original Research BACKGROUND: Prior studies have reported that the validity of autism spectrum disorder (ASD) diagnoses recorded in the Clinical Practice Research Datalink (CPRD) was high; however, diagnostic criteria and screening practices have changed since the last study was published in 2004. OBJECTIVES: 1) To calculate the positive predictive value (PPV) of ASD diagnoses recorded in the CPRD compared to original medical records and 2) to describe characteristics of cases and use of clinical codes that support the ASD diagnosis as recorded in the electronic data by general practitioners over time. METHODS: We identified children with a code for ASD (autism spectrum disorder, autism, Asperger’s, or pervasive developmental disorder) in the CPRD from 1990 to 2014. We evaluated presence of codes in the electronic medical record indicating the presence of developmental delay, speech delay, behavioral problems, and other supporting clinical codes (e.g., therapy, referrals, etc.). We also evaluated changes in recording of these clinical codes over time. We compared the information present in the electronic medical record to original medical records for a sample of cases and calculated PPVs of ASD diagnoses recorded in the CPRD. RESULTS: We identified 2154 children with a code for ASD. The mean age at diagnosis was 5.8 years, and 84% of cases were male. The majority (78.4%) had 1 ASD diagnosis code in their electronic medical record. Approximately half of the cases had a code indicating behavioral problem, developmental delay, or speech delay, and 24.7% had a code indicating specialist referral or visit. After review of original medical records, the PPV of ASD diagnoses recorded in the CPRD was 91.9%. CONCLUSION: The results of this study suggest that ASD diagnoses recorded in the CPRD are reliable and can be used with confidence to study ASD. Dove Medical Press 2017-09-15 /pmc/articles/PMC5608225/ /pubmed/28979165 http://dx.doi.org/10.2147/CLEP.S139107 Text en © 2017 Hagberg and Jick. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Hagberg, Katrina Wilcox Jick, Susan S Validation of autism spectrum disorder diagnoses recorded in the Clinical Practice Research Datalink, 1990–2014 |
title | Validation of autism spectrum disorder diagnoses recorded in the Clinical Practice Research Datalink, 1990–2014 |
title_full | Validation of autism spectrum disorder diagnoses recorded in the Clinical Practice Research Datalink, 1990–2014 |
title_fullStr | Validation of autism spectrum disorder diagnoses recorded in the Clinical Practice Research Datalink, 1990–2014 |
title_full_unstemmed | Validation of autism spectrum disorder diagnoses recorded in the Clinical Practice Research Datalink, 1990–2014 |
title_short | Validation of autism spectrum disorder diagnoses recorded in the Clinical Practice Research Datalink, 1990–2014 |
title_sort | validation of autism spectrum disorder diagnoses recorded in the clinical practice research datalink, 1990–2014 |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608225/ https://www.ncbi.nlm.nih.gov/pubmed/28979165 http://dx.doi.org/10.2147/CLEP.S139107 |
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