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Enhanced pyruvate dehydrogenase activity improves cardiac outcomes in a murine model of cardiac arrest

RATIONALE: Post-ischemic changes in cellular metabolism alter myocardial and neurological function. Pyruvate dehydrogenase (PDH), the limiting step in mitochondrial glucose oxidation, is inhibited by increased expression of PDH kinase (PDK) during ischemia/reperfusion injury. This results in decreas...

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Detalles Bibliográficos
Autores principales:	Piao, Lin, Fang, Yong-Hu, Kubler, Manfred M., Donnino, Michael W., Sharp, Willard W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608301/ https://www.ncbi.nlm.nih.gov/pubmed/28934276 http://dx.doi.org/10.1371/journal.pone.0185046

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