Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele

The contribution of the tumor microenvironment to the development of pancreatic adenocarcinoma (PDAC) is unclear. The LSL-Kras(G12D/+);LSL-p53(R172H/+);Pdx-1-Cre (KPC) tumor model, which is widely utilized to faithfully recapitulate human pancreatic cancer, depends on Cre-mediated recombination in t...

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Detalles Bibliográficos
Autores principales: Wu, Jinghai, Liu, Xin, Nayak, Sunayana G., Pitarresi, Jason R., Cuitiño, Maria C., Yu, Lianbo, Hildreth, Blake E., Thies, Katie A., Schilling, Daniel J., Fernandez, Soledad A., Leone, Gustavo, Ostrowski, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608307/
https://www.ncbi.nlm.nih.gov/pubmed/28934293
http://dx.doi.org/10.1371/journal.pone.0184984

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