Activation of phosphatidylinositol 3-kinase/AKT/snail signaling pathway contributes to epithelial-mesenchymal transition-induced multi-drug resistance to sorafenib in hepatocellular carcinoma cells

Sorafenib, an orally available kinase inhibitor, is the standard first-line systemic drug for advanced hepatocellular carcinoma (HCC), and it exerts potent inhibitory activity against epithelial–mesenchymal transition (EMT) and multidrug resistance (MDR) by inhibiting mitogen-activated protein kinas...

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Detalles Bibliográficos
Autores principales: Dong, Jiejie, Zhai, Bo, Sun, Weihua, Hu, Fengli, Cheng, Hao, Xu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608310/
https://www.ncbi.nlm.nih.gov/pubmed/28934275
http://dx.doi.org/10.1371/journal.pone.0185088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608310/
https://www.ncbi.nlm.nih.gov/pubmed/28934275
http://dx.doi.org/10.1371/journal.pone.0185088

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