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In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication
The ability of HIV to establish a long-lived latent infection within resting CD4+ T cells leads to persistence and episodic resupply of the virus in patients treated with antiretroviral therapy (ART), thereby preventing eradication of the disease. Protein kinase C (PKC) modulators such as bryostatin...
Autores principales: | Marsden, Matthew D., Loy, Brian A., Wu, Xiaomeng, Ramirez, Christina M., Schrier, Adam J., Murray, Danielle, Shimizu, Akira, Ryckbosch, Steven M., Near, Katherine E., Chun, Tae-Wook, Wender, Paul A., Zack, Jerome A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608406/ https://www.ncbi.nlm.nih.gov/pubmed/28934369 http://dx.doi.org/10.1371/journal.ppat.1006575 |
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