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Cost-efficient vaccination protocols for network epidemiology

We investigate methods to vaccinate contact networks—i.e. removing nodes in such a way that disease spreading is hindered as much as possible—with respect to their cost-efficiency. Any real implementation of such protocols would come with costs related both to the vaccination itself, and gathering o...

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Detalles Bibliográficos
Autores principales: Holme, Petter, Litvak, Nelly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608431/
https://www.ncbi.nlm.nih.gov/pubmed/28892481
http://dx.doi.org/10.1371/journal.pcbi.1005696
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author Holme, Petter
Litvak, Nelly
author_facet Holme, Petter
Litvak, Nelly
author_sort Holme, Petter
collection PubMed
description We investigate methods to vaccinate contact networks—i.e. removing nodes in such a way that disease spreading is hindered as much as possible—with respect to their cost-efficiency. Any real implementation of such protocols would come with costs related both to the vaccination itself, and gathering of information about the network. Disregarding this, we argue, would lead to erroneous evaluation of vaccination protocols. We use the susceptible-infected-recovered model—the generic model for diseases making patients immune upon recovery—as our disease-spreading scenario, and analyze outbreaks on both empirical and model networks. For different relative costs, different protocols dominate. For high vaccination costs and low costs of gathering information, the so-called acquaintance vaccination is the most cost efficient. For other parameter values, protocols designed for query-efficient identification of the network’s largest degrees are most efficient.
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spelling pubmed-56084312017-10-09 Cost-efficient vaccination protocols for network epidemiology Holme, Petter Litvak, Nelly PLoS Comput Biol Research Article We investigate methods to vaccinate contact networks—i.e. removing nodes in such a way that disease spreading is hindered as much as possible—with respect to their cost-efficiency. Any real implementation of such protocols would come with costs related both to the vaccination itself, and gathering of information about the network. Disregarding this, we argue, would lead to erroneous evaluation of vaccination protocols. We use the susceptible-infected-recovered model—the generic model for diseases making patients immune upon recovery—as our disease-spreading scenario, and analyze outbreaks on both empirical and model networks. For different relative costs, different protocols dominate. For high vaccination costs and low costs of gathering information, the so-called acquaintance vaccination is the most cost efficient. For other parameter values, protocols designed for query-efficient identification of the network’s largest degrees are most efficient. Public Library of Science 2017-09-11 /pmc/articles/PMC5608431/ /pubmed/28892481 http://dx.doi.org/10.1371/journal.pcbi.1005696 Text en © 2017 Holme, Litvak http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Holme, Petter
Litvak, Nelly
Cost-efficient vaccination protocols for network epidemiology
title Cost-efficient vaccination protocols for network epidemiology
title_full Cost-efficient vaccination protocols for network epidemiology
title_fullStr Cost-efficient vaccination protocols for network epidemiology
title_full_unstemmed Cost-efficient vaccination protocols for network epidemiology
title_short Cost-efficient vaccination protocols for network epidemiology
title_sort cost-efficient vaccination protocols for network epidemiology
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608431/
https://www.ncbi.nlm.nih.gov/pubmed/28892481
http://dx.doi.org/10.1371/journal.pcbi.1005696
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