AP-1 Oligodeoxynucleotides Reduce Aortic Elastolysis in a Murine Model of Marfan Syndrome

Marfan syndrome is characterized by high expression of matrix metalloproteinases (MMPs) in aortic smooth muscle cells (AoSMCs) associated with medial elastolysis and aortic root aneurysm. We aimed to reduce aortic elastolysis through decrease of MMP expression with decoy oligodeoxynucleotides (dODNs...

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Detalles Bibliográficos
Autores principales: Arif, Rawa, Zaradzki, Marcin, Remes, Anca, Seppelt, Philipp, Kunze, Reiner, Schröder, Hannes, Schwill, Simon, Ensminger, Stephan M., Robinson, Peter N., Karck, Matthias, Müller, Oliver J., Hecker, Markus, Wagner, Andreas H., Kallenbach, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608502/
https://www.ncbi.nlm.nih.gov/pubmed/29246325
http://dx.doi.org/10.1016/j.omtn.2017.08.014

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