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Acute respiratory distress syndrome; A rare complication caused by usage of ruxolitinib
Ruxolitinib-associated acute respiratory distress has rarely been reported, mostly due to discontinuation of treatment. Herein we report a 58-year-old male patient with primary myelofibrosis who presented with malaise and dyspnea 15 days after initiation of the treatment. The patient was diagnosed a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608559/ https://www.ncbi.nlm.nih.gov/pubmed/28970999 http://dx.doi.org/10.1016/j.rmcr.2017.09.003 |
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author | Kerget, Bugra Araz, Omer Ucar, Elif Yilmazel Akgun, Metin Sağlam, Leyla |
author_facet | Kerget, Bugra Araz, Omer Ucar, Elif Yilmazel Akgun, Metin Sağlam, Leyla |
author_sort | Kerget, Bugra |
collection | PubMed |
description | Ruxolitinib-associated acute respiratory distress has rarely been reported, mostly due to discontinuation of treatment. Herein we report a 58-year-old male patient with primary myelofibrosis who presented with malaise and dyspnea 15 days after initiation of the treatment. The patient was diagnosed as mild acute respiratory distress syndrome (ARDS). After excluding other potential causes such as infection and cardiac pathologies, it was considered secondary to ruxolitinib use. The medication was discontinued and 1 mg/kg methylprednisolone was given to prevent cytokine rebound syndrome and continuous positive airway pressure therapy was prescribed for ARDS. Symptomatic improvement and complete radiological resolution was observed. This case suggests that ARDS may develop secondary to ruxolitinib use and ARDS should be keep in mind in the cases with respiratory symptoms who were on treatment. |
format | Online Article Text |
id | pubmed-5608559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-56085592017-10-02 Acute respiratory distress syndrome; A rare complication caused by usage of ruxolitinib Kerget, Bugra Araz, Omer Ucar, Elif Yilmazel Akgun, Metin Sağlam, Leyla Respir Med Case Rep Case Report Ruxolitinib-associated acute respiratory distress has rarely been reported, mostly due to discontinuation of treatment. Herein we report a 58-year-old male patient with primary myelofibrosis who presented with malaise and dyspnea 15 days after initiation of the treatment. The patient was diagnosed as mild acute respiratory distress syndrome (ARDS). After excluding other potential causes such as infection and cardiac pathologies, it was considered secondary to ruxolitinib use. The medication was discontinued and 1 mg/kg methylprednisolone was given to prevent cytokine rebound syndrome and continuous positive airway pressure therapy was prescribed for ARDS. Symptomatic improvement and complete radiological resolution was observed. This case suggests that ARDS may develop secondary to ruxolitinib use and ARDS should be keep in mind in the cases with respiratory symptoms who were on treatment. Elsevier 2017-09-18 /pmc/articles/PMC5608559/ /pubmed/28970999 http://dx.doi.org/10.1016/j.rmcr.2017.09.003 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Kerget, Bugra Araz, Omer Ucar, Elif Yilmazel Akgun, Metin Sağlam, Leyla Acute respiratory distress syndrome; A rare complication caused by usage of ruxolitinib |
title | Acute respiratory distress syndrome; A rare complication caused by usage of ruxolitinib |
title_full | Acute respiratory distress syndrome; A rare complication caused by usage of ruxolitinib |
title_fullStr | Acute respiratory distress syndrome; A rare complication caused by usage of ruxolitinib |
title_full_unstemmed | Acute respiratory distress syndrome; A rare complication caused by usage of ruxolitinib |
title_short | Acute respiratory distress syndrome; A rare complication caused by usage of ruxolitinib |
title_sort | acute respiratory distress syndrome; a rare complication caused by usage of ruxolitinib |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608559/ https://www.ncbi.nlm.nih.gov/pubmed/28970999 http://dx.doi.org/10.1016/j.rmcr.2017.09.003 |
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