IDH2 deficiency increases the liver susceptibility to ischemia-reperfusion injury via increased mitochondrial oxidative injury

Mitochondrial NADP(+)-dependent isocitrate dehydrogenase 2 (IDH2) is a major producer of mitochondrial NADPH, required for glutathione (GSH)-associated mitochondrial antioxidant systems including glutathione peroxidase (GPx) and glutathione reductase (GR). Here, we investigated the role of IDH2 in h...

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Detalles Bibliográficos
Autores principales: Han, Sang Jun, Choi, Hong Seok, Kim, Jee In, Park, Jeen-Woo, Park, Kwon Moo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608561/
https://www.ncbi.nlm.nih.gov/pubmed/28938192
http://dx.doi.org/10.1016/j.redox.2017.09.003

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