Human DBR1 modulates the recycling of snRNPs to affect alternative RNA splicing and contributes to the suppression of cancer development

The contribution of RNA processing to tumorigenesis is understudied. Here, we report that the human RNA debranching enzyme (hDBR1), when inappropriately regulated, induces oncogenesis by causing RNA processing defects, for example, splicing defects. We found that wild-type p53 and hypoxia-inducible...

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Detalles Bibliográficos
Autores principales: Han, B, Park, H K, Ching, T, Panneerselvam, J, Wang, H, Shen, Y, Zhang, J, Li, L, Che, R, Garmire, L, Fei, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608638/
https://www.ncbi.nlm.nih.gov/pubmed/28504715
http://dx.doi.org/10.1038/onc.2017.150

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