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IgG1 memory B cells keep the memory of IgE responses

The unique differentiation of IgE cells suggests unconventional mechanisms of IgE memory. IgE germinal centre cells are transient, most IgE cells are plasma cells, and high affinity IgE is produced by the switching of IgG1 cells to IgE. Here we investigate the function of subsets of IgG1 memory B ce...

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Detalles Bibliográficos
Autores principales: He, Jin-Shu, Subramaniam, Sharrada, Narang, Vipin, Srinivasan, Kandhadayar, Saunders, Sean P., Carbajo, Daniel, Wen-Shan, Tsao, Hidayah Hamadee, Nur, Lum, Josephine, Lee, Andrea, Chen, Jinmiao, Poidinger, Michael, Zolezzi, Francesca, Lafaille, Juan J., Curotto de Lafaille, Maria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608722/
https://www.ncbi.nlm.nih.gov/pubmed/28935935
http://dx.doi.org/10.1038/s41467-017-00723-0
Descripción
Sumario:The unique differentiation of IgE cells suggests unconventional mechanisms of IgE memory. IgE germinal centre cells are transient, most IgE cells are plasma cells, and high affinity IgE is produced by the switching of IgG1 cells to IgE. Here we investigate the function of subsets of IgG1 memory B cells in IgE production and find that two subsets of IgG1 memory B cells, CD80(+)CD73(+) and CD80(−)CD73(−), contribute distinctively to the repertoires of high affinity pathogenic IgE and low affinity non-pathogenic IgE. Furthermore, repertoire analysis indicates that high affinity IgE and IgG1 plasma cells differentiate from rare CD80(+)CD73(+) high affinity memory clones without undergoing further mutagenesis. By identifying the cellular origin of high affinity IgE and the clonal selection of high affinity memory B cells into the plasma cell fate, our findings provide fundamental insights into the pathogenesis of allergies, and on the mechanisms of antibody production in memory B cell responses.